Dhasmana K M, Banerjee A K, Saxena P R
Department of Anaesthesiology, Erasmus University Rotterdam, The Netherlands.
Eur J Pharmacol. 1989 Sep 13;168(2):257-60. doi: 10.1016/0014-2999(89)90574-8.
Intrathecal administration of ketanserin and phentolamine elicited dose-dependent falls in arterial blood pressure and heart rate in anaesthetized rats without attenuation of the pressor responses to i.v. injections of phenylephrine. It is concluded that both ketanserin and phentolamine can decrease arterial blood pressure by acting within the spinal cord.
在麻醉大鼠中，鞘内注射酮色林和酚妥拉明可引起动脉血压和心率呈剂量依赖性下降，且不减弱静脉注射去氧肾上腺素引起的升压反应。得出的结论是，酮色林和酚妥拉明均可通过作用于脊髓来降低动脉血压。
