Murata A, Ohtani M, Muramatsu K, Kobori S, Tomioka S, Matsuda S
Department of Preventive Medicine and Community Health, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan.
Pediatr Obes. 2016 Jun;11(3):174-80. doi: 10.1111/ijpo.12041. Epub 2015 Jun 10.
Insufficient information is available on the relationship between obesity and outcome of paediatric patients with acute pancreatitis.
This study aimed to investigate the effect of obesity on outcomes of paediatric patients with acute pancreatitis based on a national administrative database.
A total of 500 cases in 416 paediatric patients with acute pancreatitis (aged 5-17 years) were referred from 260 hospitals between 2010 and 2012 in Japan. Patients were divided into two groups according to the presence of obesity: with obesity (n = 65) and without obesity (n = 435). Patient data were collected from the administrative database to compare the prevalence of severe acute pancreatitis, in-hospital mortality, length of stay (LOS) and medical costs between the groups.
Both prevalence of severe acute pancreatitis and in-hospital mortality were significantly higher in paediatric patients with obesity than those without (36.9% vs. 16.3% and 3.1% vs. 0.0%; P < 0.001, respectively). Longer LOS and higher medical costs were also observed in paediatric patients with obesity (25.7 vs. 15.2 days, P < 0.001 and 14 169.5 vs. 7457.7 US dollars, P < 0.001, respectively).
This study demonstrated that obesity significantly influenced the outcomes of paediatric acute pancreatitis.
关于肥胖与小儿急性胰腺炎患者预后之间的关系，目前可用信息不足。
本研究旨在基于国家行政数据库，调查肥胖对小儿急性胰腺炎患者预后的影响。
2010年至2012年期间，从日本260家医院转诊了416例小儿急性胰腺炎患者（年龄5 - 17岁）共500例病例。根据是否肥胖将患者分为两组：肥胖组（n = 65）和非肥胖组（n = 435）。从行政数据库收集患者数据，以比较两组之间重症急性胰腺炎的患病率、住院死亡率、住院时间（LOS）和医疗费用。
肥胖小儿患者的重症急性胰腺炎患病率和住院死亡率均显著高于非肥胖患者（分别为36.9%对16.3%和3.1%对0.0%；P均<0.001）。肥胖小儿患者的住院时间也更长，医疗费用更高（分别为25.7天对15.2天，P<0.001和14169.5美元对7457.7美元，P<0.001）。
本研究表明，肥胖对小儿急性胰腺炎的预后有显著影响。
