Kudayeva I V, Masnavieva L B, Popkova O V, Dyakovitch O A
Med Tr Prom Ekol. 2015(4):11-5.
Prospective cohort study covered individuals with preclinical and clinical stages, in early and remote periods of chronic mercurial intoxication and intact workers with length of service over 5 years. Tests included levels of serotonine, histamine, dophamine, norepinephrine, epinephrine and their metabolites (normetanephrine and metanephrine). Increased level of norepinephrine at clinical stage of mental sphere disorders was partially compensated by its transformation into normetanephrine and not associated with increase in its metabolites levels at early stage of chronic mercury intoxication. Remote period of the intoxication was characterized also by increased levels of dophamine, serotonine and histamine.
前瞻性队列研究涵盖了处于临床前期和临床期的个体,包括慢性汞中毒早期和远期的患者,以及工龄超过5年的健康工人。检测项目包括血清素、组胺、多巴胺、去甲肾上腺素、肾上腺素及其代谢产物(去甲变肾上腺素和变肾上腺素)的水平。在精神领域障碍临床期,去甲肾上腺素水平升高部分通过其转化为去甲变肾上腺素得到代偿,且与慢性汞中毒早期其代谢产物水平升高无关。汞中毒远期还表现为多巴胺、血清素和组胺水平升高。