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吸入杀虫剂喷雾对大鼠学习和记忆的影响。

Effect of inhalation of insecticide spray on learning and memory in rats.

作者信息

Mathew R, Verghese J, Venkataraman B V, Joseph T

出版信息

Indian J Exp Biol. 1989 Mar;27(3):258-60.

PMID:2606533
Abstract

Acute exposure to insecticide (Baygon-spray; 5 ml/animal/5 min) inhalation in rats did not affect the learning process but produced a significant loss of memory (P less than 0.01 less than 0.001) whereas chronic exposure (one exposure per day for three weeks) produced a significant delay in learning (P less than 0.05) and memory (P less than 0.01). Acetylcholinesterase activity in brain after acute and chronic exposure declined significantly (P less than 0.01) during the learning process but returned to normal after 24 hr.

摘要

大鼠急性吸入杀虫剂(拜戈喷雾剂;每只动物5毫升/5分钟)不会影响学习过程,但会导致显著的记忆丧失(P<0.01<P<0.001),而慢性暴露(每天一次,持续三周)会导致学习(P<0.05)和记忆(P<0.01)出现显著延迟。急性和慢性暴露后,大脑中的乙酰胆碱酯酶活性在学习过程中显著下降(P<0.01),但24小时后恢复正常。

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