Kishore Aravind, Blake Lauren, Wang Chengming, Ba Shan, Gross Gary
J Biomech Eng. 2015 Aug;137(8):081011. doi: 10.1115/1.4030825. Epub 2015 Jun 23.
Computational fluid dynamics (CFD) was used to simulate air flow changes in reconstructed nasal passages based on magnetic resonance imaging (MRI) data from a previous clinical study of 0.05% Oxymetazoline (Vicks Sinex Micromist®). Total-pressure boundary conditions were uniquely applied to accommodate low patency subjects. Net nasal resistance, the primary simulation outcome, was determined using a parallel-circuit analogy and compared across treatments. Relative risk (RR) calculations show that for a 50% reduction in nasal resistance, subjects treated with Sinex® are 9.1 times more likely to achieve this after 8 hr, and 3.2 times more likely after 12 hr compared to Sham.
计算流体动力学（CFD）基于先前一项关于0.05%羟甲唑啉（Vicks Sinex Micromist®）的临床研究中的磁共振成像（MRI）数据，用于模拟重建鼻腔通道内的气流变化。采用独特的总压边界条件以适应鼻腔通畅性低的受试者。主要模拟结果——净鼻阻力，通过并联电路类比法确定，并在不同治疗方法之间进行比较。相对风险（RR）计算表明，为使鼻阻力降低50%，与使用安慰剂相比，使用Sinex®治疗的受试者在8小时后实现这一目标的可能性高9.1倍，在12小时后高3.2倍。
