Freeman R A, Rozman K K, Wilson A G
Monsanto Co., St. Louis, MO 63167.
Health Phys. 1989;57 Suppl 1:139-45; discussion 145-7. doi: 10.1097/00004032-198907001-00017.
A physiologically based pharmacokinetic model was developed to describe the distribution of hexachlorobenzene (HCB) in the rat after oral administration or injection. The model was based on flow-limited blood perfusion of HCB to tissues and organs of the body. A set of simultaneous differential equations were solved for the different tissue concentrations as a functions of time. The model allowed for elimination of HCB by excretion. The model also allowed for differential growth of various tissues over the course of an experiment. Computer simulations using the model indicated that growth of animals during the course of dosing experiments can greatly increase the apparent half-life of HCB.
建立了一个基于生理学的药代动力学模型，以描述大鼠口服或注射六氯苯（HCB）后的分布情况。该模型基于HCB向身体组织和器官的血流受限灌注。针对不同组织浓度作为时间的函数，求解了一组联立微分方程。该模型考虑了通过排泄消除HCB的情况。该模型还考虑了在实验过程中各种组织的差异生长。使用该模型的计算机模拟表明，给药实验过程中动物的生长会大大增加HCB的表观半衰期。
