Powell Timothy R, Fernandes Cathy, Schalkwyk Leonard C
Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom.
Curr Protoc Mouse Biol. 2012 Jun 1;2(2):119-27. doi: 10.1002/9780470942390.mo110176.
Overlapping characteristics between human depressive phenotypes and mouse behaviors has led to the creation of mouse models that aim to investigate the pathophysiology and treatment of unipolar depression. Behavioral tests in mice are used to assess and quantify the extent to which a mouse model displays a depression-like phenotype. The forced swim test and tail suspension test, sucrose preference test, and novelty suppressed feeding tests all aim to measure different components of depression. However, each one of these tests has different strengths and weaknesses in terms of predictive, face and construct validities. Furthermore, the responses to these tests vary greatly depending on strain of mouse. Depression-related behavioral tests are an extremely useful investigative tool in unearthing causes and predicting treatment outcomes in human depression, but as this review demonstrates, the comprehension of the finer details are extremely important in the design, analysis, and evaluation of such mouse studies. Curr. Protoc. Mouse Biol. 2:119-127 © 2012 by John Wiley & Sons, Inc.
人类抑郁表型与小鼠行为之间的重叠特征促使了旨在研究单相抑郁症病理生理学和治疗方法的小鼠模型的建立。小鼠行为测试用于评估和量化小鼠模型表现出抑郁样表型的程度。强迫游泳试验、悬尾试验、蔗糖偏好试验和新奇抑制摄食试验均旨在测量抑郁症的不同组成部分。然而，这些测试中的每一项在预测效度、表面效度和结构效度方面都有不同的优缺点。此外，小鼠对这些测试的反应因小鼠品系的不同而有很大差异。与抑郁症相关的行为测试是挖掘人类抑郁症病因和预测治疗结果的极其有用的研究工具，但正如本综述所表明的，在设计、分析和评估此类小鼠研究时，理解更细微的细节极为重要。《当代小鼠生物学实验指南》2:119 - 127 © 2012 约翰威立父子公司
