• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

叶酸-碲化镉量子点共轭物及其在癌细胞靶向中的应用。

Folic acid-CdTe quantum dot conjugates and their applications for cancer cell targeting.

作者信息

Suriamoorthy Preethi, Zhang Xing, Hao Guiyang, Joly Alan G, Singh Surya, Hossu Marius, Sun Xiankai, Chen Wei

机构信息

Department of Physics, The University of Texas at Arlington, Arlington, TX 76019-0059 USA.

Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, TX USA.

出版信息

Cancer Nanotechnol. 2010;1(1-6):19-28. doi: 10.1007/s12645-010-0003-3. Epub 2010 Jul 31.

DOI:10.1007/s12645-010-0003-3
PMID:26069476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4451629/
Abstract

In this study, we report the preparation, luminescence, and targeting properties of folic acid-CdTe quantum dot conjugates. Water-soluble CdTe quantum dots were synthesized and conjugated with folic acid using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide-N-hydroxysuccinimide chemistry. The influence of folic acid on the luminescence properties of CdTe quantum dots was investigated, and no energy transfer between them was observed. To investigate the efficiency of folic acid-CdTe nanoconjugates for tumor targeting, pure CdTe quantum dots and folic acid-coated CdTe quantum dots were incubated with human nasopharyngeal epidermal carcinoma cell line with positive expressing folic acid receptors (KB cells) and lung cancer cells without expression of folic acid receptors (A549 cells). For the cancer cells with positive folate receptors (KB cells), the uptake for CdTe quantum dots is very low, but for folic acid-CdTe nanoconjugates, the uptake is very high. For the lung cancer cells without folate receptors (A549 cells), the uptake for folic acid-CdTe nanoconjugates is also very low. The results indicate that folic acid is an effective targeting molecule for tumor cells with overexpressed folate receptors.

摘要

在本研究中，我们报道了叶酸 - 碲化镉量子点共轭物的制备、发光及靶向特性。采用1 - 乙基 - 3 -（3 - 二甲基氨基丙基）碳二亚胺 - N - 羟基琥珀酰亚胺化学方法合成了水溶性碲化镉量子点，并将其与叶酸共轭。研究了叶酸对碲化镉量子点发光特性的影响，未观察到它们之间的能量转移。为了研究叶酸 - 碲化镉纳米共轭物的肿瘤靶向效率，将纯碲化镉量子点和叶酸包覆的碲化镉量子点与人鼻咽癌表皮癌细胞系（叶酸受体阳性表达的KB细胞）和无叶酸受体表达的肺癌细胞（A549细胞）共同孵育。对于叶酸受体阳性的癌细胞（KB细胞），碲化镉量子点的摄取量非常低，但对于叶酸 - 碲化镉纳米共轭物，摄取量非常高。对于无叶酸受体的肺癌细胞（A549细胞），叶酸 - 碲化镉纳米共轭物的摄取量也非常低。结果表明，叶酸是叶酸受体过表达的肿瘤细胞的有效靶向分子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/2f04d776fc44/12645_2010_3_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/7e4a1aa1b2a5/12645_2010_3_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/c1a12e80ccff/12645_2010_3_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/8e4afff87529/12645_2010_3_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/78f505bb0a82/12645_2010_3_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/dd952161c4c5/12645_2010_3_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/92a7745debbe/12645_2010_3_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/99f14aa8a830/12645_2010_3_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/1b7bcc119fc9/12645_2010_3_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/3dc875c0ddb8/12645_2010_3_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/15d9b2bd6313/12645_2010_3_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/6f69ea31580e/12645_2010_3_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/2f04d776fc44/12645_2010_3_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/7e4a1aa1b2a5/12645_2010_3_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/c1a12e80ccff/12645_2010_3_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/8e4afff87529/12645_2010_3_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/78f505bb0a82/12645_2010_3_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/dd952161c4c5/12645_2010_3_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/92a7745debbe/12645_2010_3_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/99f14aa8a830/12645_2010_3_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/1b7bcc119fc9/12645_2010_3_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/3dc875c0ddb8/12645_2010_3_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/15d9b2bd6313/12645_2010_3_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/6f69ea31580e/12645_2010_3_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab57/4451629/2f04d776fc44/12645_2010_3_Fig12_HTML.jpg

相似文献

1
Folic acid-CdTe quantum dot conjugates and their applications for cancer cell targeting.叶酸-碲化镉量子点共轭物及其在癌细胞靶向中的应用。
Cancer Nanotechnol. 2010;1(1-6):19-28. doi: 10.1007/s12645-010-0003-3. Epub 2010 Jul 31.
2
Cancer Cell Targeting Using Folic Acid/Anti-HER2 Antibody Conjugated Fluorescent CdSe/CdS/ZnS-MPA and CdTe-MSA Quantum Dots.使用叶酸/抗HER2抗体偶联的荧光CdSe/CdS/ZnS-MPA和CdTe-MSA量子点靶向癌细胞
J Nanosci Nanotechnol. 2015 Dec;15(12):9382-95. doi: 10.1166/jnn.2015.10767.
3
Conjugates of folic acids with BSA-coated quantum dots for cancer cell targeting and imaging by single-photon and two-photon excitation.BSA 偶联叶酸量子点用于单光子和双光子激发的癌细胞靶向和成像。
J Biol Inorg Chem. 2011 Jan;16(1):117-23. doi: 10.1007/s00775-010-0709-z. Epub 2010 Oct 2.
4
Cancer Cell Targeting Using Folic Acid/Anti-HER2 Antibody Conjugated Fluorescent CdSe/CdS/ZnS-Mercaptopropionic Acid and CdTe-Mercaptosuccinic Acid Quantum Dots.使用叶酸/抗HER2抗体偶联的荧光CdSe/CdS/ZnS-巯基丙酸和CdTe-巯基琥珀酸量子点靶向癌细胞
J Nanosci Nanotechnol. 2016 Jan;16(1):130-43. doi: 10.1166/jnn.2016.10825.
5
Quantum dot-folic acid conjugates as potential photosensitizers in photodynamic therapy of cancer.量子点-叶酸偶联物作为光动力疗法治疗癌症的潜在光敏剂。
Photochem Photobiol Sci. 2011 May;10(5):842-51. doi: 10.1039/c0pp00380h. Epub 2011 Apr 9.
6
Tumor cell targeting using folate-conjugated fluorescent quantum dots and receptor-mediated endocytosis.利用叶酸偶联荧光量子点和受体介导的内吞作用进行肿瘤细胞靶向
Clin Chem. 2009 May;55(5):955-63. doi: 10.1373/clinchem.2008.113423. Epub 2009 Mar 12.
7
Bioconjugation of luminescent silicon quantum dots for selective uptake by cancer cells.将发光硅量子点进行生物共轭，使其被癌细胞选择性摄取。
Bioconjug Chem. 2011 Jun 15;22(6):1081-8. doi: 10.1021/bc100552p. Epub 2011 May 18.
8
Foliate-Targeting Quantum Dots--Cyclodextrin Nanocarrier for Efficient Delivery of Unsymmetrical Bisacridines to Lung and Prostate Cancer Cells.叶状靶向量子点 - 环糊精纳米载体，用于将不对称双吖啶碱有效递送至肺癌和前列腺癌细胞。
Int J Mol Sci. 2022 Jan 23;23(3):1261. doi: 10.3390/ijms23031261.
9
Facile synthesis and photophysical characterization of luminescent CdTe quantum dots for Forster resonance energy transfer based immunosensing of staphylococcal enterotoxin B.基于Förster 共振能量转移的免疫传感检测金黄色葡萄球菌肠毒素 B 的荧光 CdTe 量子点的简便合成及光物理特性研究。
Luminescence. 2013 Nov-Dec;28(6):827-35. doi: 10.1002/bio.2440. Epub 2012 Nov 29.
10
Bioconjugation of CdTe quantum dot for the detection of 2,4-dichlorophenoxyacetic acid by competitive fluoroimmunoassay based biosensor.用于基于竞争荧光免疫分析的生物传感器检测2,4-二氯苯氧乙酸的碲化镉量子点生物共轭物
Biosens Bioelectron. 2009 Feb 15;24(6):1615-20. doi: 10.1016/j.bios.2008.08.042. Epub 2008 Sep 2.

引用本文的文献

1
Utilisation of Carbon Quantum Dots from Hazelnut Husk for Folic Acid (FA) Detection: An Innovative Approach.利用榛子壳制备的碳量子点检测叶酸（FA）：一种创新方法。
Protein J. 2025 Mar 8. doi: 10.1007/s10930-025-10249-w.
2
Preparation of Fluorescent Carbon Dots Composites and Their Potential Applications in Biomedicine and Drug Delivery-A Review.荧光碳点复合材料的制备及其在生物医学和药物递送中的潜在应用——综述
Pharmaceutics. 2022 Nov 16;14(11):2482. doi: 10.3390/pharmaceutics14112482.
3
Folic acid modified FeO nanoclusters by a one-step ultrasonic technique for drug delivery and MR imaging.

本文引用的文献

1
Folate receptor-targeted quantum dot liposomes as fluorescence probes.叶酸受体靶向量子点脂质体作为荧光探针
J Drug Target. 2009 Aug;17(7):502-11. doi: 10.1080/10611860903013248.
2
Bio-conjugated luminescent quantum dots of doped ZnS: a cyto-friendly system for targeted cancer imaging.生物共轭的掺杂硫化锌发光量子点：一种用于靶向癌症成像的细胞友好型系统。
Nanotechnology. 2009 Feb 11;20(6):065102. doi: 10.1088/0957-4484/20/6/065102. Epub 2009 Jan 14.
3
Multimodal-luminescence core-shell nanocomposites for targeted imaging of tumor cells.
通过一步超声技术制备叶酸修饰的FeO纳米簇用于药物递送和磁共振成像。
RSC Adv. 2020 Jan 31;10(9):5294-5303. doi: 10.1039/c9ra09670a. eCollection 2020 Jan 29.
4
Facile Fabrication of Highly Fluorescent N-Doped Carbon Quantum Dots Using an Ultrasonic-Assisted Hydrothermal Method: Optical Properties and Cell Imaging.利用超声辅助水热法简便制备高荧光氮掺杂碳量子点：光学性质与细胞成像
ACS Omega. 2021 Nov 22;6(48):32904-32916. doi: 10.1021/acsomega.1c04903. eCollection 2021 Dec 7.
5
CuS@PDA-FA nanocomposites: a dual stimuli-responsive DOX delivery vehicle with ultrahigh loading level for synergistic photothermal-chemotherapies on breast cancer.CuS@PDA-FA 纳米复合材料：一种具有超高载药量的双重刺激响应 DOX 递送载体，用于协同光热-化学疗法治疗乳腺癌。
J Mater Chem B. 2020 Feb 21;8(7):1396-1404. doi: 10.1039/c9tb02440a. Epub 2020 Jan 23.
6
X-ray induced photodynamic therapy with copper-cysteamine nanoparticles in mice tumors.X 射线诱导的载半胱氨酸铜纳米粒子光动力疗法在小鼠肿瘤中的应用。
Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16823-16828. doi: 10.1073/pnas.1900502116. Epub 2019 Aug 1.
7
2-Deoxyglucose-Modified Folate Derivative: Self-Assembling Nanoparticle Able to Load Cisplatin.2-脱氧葡萄糖修饰叶酸衍生物：自组装纳米颗粒，能够负载顺铂。
Molecules. 2019 Mar 19;24(6):1084. doi: 10.3390/molecules24061084.
8
Targeting of Apoptotic Cells Using Functionalized Fe₂O₃ Nanoparticles.使用功能化Fe₂O₃纳米颗粒靶向凋亡细胞。
Nanomaterials (Basel). 2015 May 26;5(2):874-884. doi: 10.3390/nano5020874.
9
Anti-cancer studies of noble metal nanoparticles synthesized using different plant extracts.使用不同植物提取物合成的贵金属纳米颗粒的抗癌研究。
Cancer Nanotechnol. 2011;2(1-6):57-65. doi: 10.1007/s12645-011-0014-8. Epub 2011 May 10.
用于肿瘤细胞靶向成像的多模态发光核壳纳米复合材料。
Chemistry. 2009;15(14):3577-84. doi: 10.1002/chem.200802261.
4
Nanoparticle fluorescence based technology for biological applications.用于生物应用的基于纳米颗粒荧光的技术。
J Nanosci Nanotechnol. 2008 Mar;8(3):1019-51. doi: 10.1166/jnn.2008.301.
5
In vitro and in vivo toxicity of CdTe nanoparticles.碲化镉纳米颗粒的体外和体内毒性
J Nanosci Nanotechnol. 2007 Feb;7(2):497-503. doi: 10.1166/jnn.2007.125.
6
Comparison of water-soluble CdTe nanoparticles synthesized in air and in nitrogen.在空气中和氮气中合成的水溶性碲化镉纳米颗粒的比较。
J Phys Chem B. 2006 Aug 31;110(34):16992-7000. doi: 10.1021/jp063085k.
7
Multicolor quantum dots for molecular diagnostics of cancer.用于癌症分子诊断的多色量子点
Expert Rev Mol Diagn. 2006 Mar;6(2):231-44. doi: 10.1586/14737159.6.2.231.
8
Description of the fluorescence intensity time trace of collections of CdSe nanocrystal quantum dots based on single quantum dot fluorescence blinking statistics.基于单量子点荧光闪烁统计的CdSe纳米晶体量子点集合的荧光强度时间轨迹描述。
Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Jan;73(1 Pt 1):011106. doi: 10.1103/PhysRevE.73.011106. Epub 2006 Jan 20.
9
Multiple wurtzite twinning in CdTe nanocrystals induced by methylphosphonic acid.甲基膦酸诱导CdTe纳米晶体中形成多个纤锌矿孪晶。
J Am Chem Soc. 2006 Jan 25;128(3):748-55. doi: 10.1021/ja054893c.
10
Spectroscopy and femtosecond dynamics of type-II CdTe/CdSe core-shell quantum dots.II型CdTe/CdSe核壳量子点的光谱学与飞秒动力学
Chemphyschem. 2006 Jan 16;7(1):222-8. doi: 10.1002/cphc.200500307.