Youssef H, Lyster G, Youssef F
St Davnet's Hospital, Monaghan, Ireland.
Int Clin Psychopharmacol. 1989 Oct;4(4):323-8. doi: 10.1097/00004850-198910000-00007.
The demography, course of illness, cognitive dysfunction and neurological consequences of long term treatment of 11 family pairs with long history of chronic schizophrenic illness were studied. There was concordance for the presence of tardive dyskinesia in 6 pairs; each of 2 brother-brother pairs; 3 brother-sister pairs and one of mother-daughter pair. There was concordance for the absence of tardive dyskinesia in 5 pairs, each of 3 father-son pairs and 2 brother-sister pairs. In schizophrenic patients the presence or absence of tardive dyskinesia in one member of the family is a risk factor for the development of the syndrome in another member with the same psychotic illness. Those pairs with tardive dyskinesia were characterized by negative symptoms of schizophrenia and evidence of intellectual deterioration.
对11对有慢性精神分裂症病史的家族进行了人口统计学、病程、认知功能障碍以及长期治疗的神经学后果研究。6对存在迟发性运动障碍；其中2对兄弟、3对兄妹和1对母女。5对不存在迟发性运动障碍，其中3对父子和2对兄妹。在精神分裂症患者中，家族中一名成员存在或不存在迟发性运动障碍是另一名患有相同精神病性疾病的家族成员发生该综合征的危险因素。那些存在迟发性运动障碍的家族成员具有精神分裂症的阴性症状和智力衰退的证据。
