Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Republic of Korea.
Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Republic of Korea.
Trends Microbiol. 2015 Sep;23(9):567-76. doi: 10.1016/j.tim.2015.05.007. Epub 2015 Jun 10.
Bacterial quorum sensing (QS)-dependent gene expression is a dynamic response to cell density. Bacteria produce costly public goods for the benefit of the population as a whole. As an example, QS rewires cellular metabolism to produce oxalate (a public good) to enable survival during the stationary phase in Burkholderia glumae, Burkholderia thailandensis, and Burkholderia pseudomallei. Recent reports showed that QS serves as a metabolic brake to maintain homeostatic primary metabolism in B. glumae and readjusts the central metabolism of Pseudomonas aeruginosa. In this review, we emphasize the dynamics and complexity of the control of gene expression by QS and discuss the metabolic costs and possible metabolic options to sustain cooperativity. We then focus on how QS influences bacterial central metabolism.
细菌群体感应 (QS) 依赖的基因表达是对细胞密度的动态响应。细菌会为了整个种群的利益而产生昂贵的公共物品。例如，QS 会重新布线细胞代谢以产生草酸盐（一种公共物品），从而使伯克霍尔德菌、泰国伯克霍尔德菌和类鼻疽伯克霍尔德菌能够在静止期存活。最近的报告表明，QS 作为一种代谢制动器，用于维持伯克霍尔德菌中稳态的主代谢，并重新调整铜绿假单胞菌的中心代谢。在这篇综述中，我们强调了 QS 控制基因表达的动态性和复杂性，并讨论了维持合作的代谢成本和可能的代谢选择。然后，我们将重点介绍 QS 如何影响细菌的中心代谢。
