Nie Ping, Xu Xiao-Long, Tang Yan-Mei, Wang Xiao-Ling, Xue Xiao-Chen, Wu Ya-Dong, Zhu Min
Department of Oral & Cranio-maxillofacial Science, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Top Priority Clinical Medical Center of Shanghai Municipal Commission of Health and Family Planning, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
Department of Stomatology, Pudong New District Oculopathy Odontopathy Dispensary, Shanghai, 201300, China.
J Huazhong Univ Sci Technolog Med Sci. 2015 Jun;35(3):464-468. doi: 10.1007/s11596-015-1454-x. Epub 2015 Jun 14.
This study aimed to use computer simulation to describe the fluid dynamic characteristics in patients with obstructive sleep apnea syndrome (OSAS) and to evaluate the difference between during quiet respiration and the Muller maneuver (MM). Seven patients with OSAS were involved to perform computed tomographic (CT) scanning during quiet respiration and the MM. CT data in DICOM format were transformed into an anatomically three-dimensional computational fluid dynamics (CFD) model of the upper airway. The velocity magnitude, relative pressure, and flow distribution were obtained. Numerical simulation of airflow was performed to discuss how the MM affected airflow in the upper airway. To measure the discrepancy, the SPSS19.0 software package was utilized for statistic analysis. The results showed that the shape of the upper airway became narrower, and the pressure decreased during the MM. The minimal cross-sectional area (MCSA) of velopharynx was significantly decreased (P<0.05) and the airflow velocity in MCSAs of velopharynx and glossopharynx significantly accelerated (P<0.05) during the MM. This study demonstrated the possibility of CFD model combined with the MM for understanding pharyngeal aerodynamics in the pathophysiology of OSAS.
本研究旨在利用计算机模拟描述阻塞性睡眠呼吸暂停低通气综合征（OSAS）患者的流体动力学特征，并评估静息呼吸与米勒动作（MM）期间的差异。纳入7例OSAS患者，在静息呼吸和MM期间进行计算机断层扫描（CT）。将DICOM格式的CT数据转换为上气道的解剖学三维计算流体动力学（CFD）模型。获得速度大小、相对压力和血流分布。进行气流数值模拟，以探讨MM如何影响上气道气流。为测量差异，使用SPSS19.0软件包进行统计分析。结果显示，MM期间上气道形状变窄，压力降低。软腭后区的最小横截面积（MCSA）显著减小（P<0.05），MM期间软腭后区和舌后区MCSA处的气流速度显著加快（P<0.05）。本研究证明了CFD模型结合MM用于理解OSAS病理生理学中咽部空气动力学的可能性。
