Donaldson Peter H, Rinehart Nicole J, Enticott Peter G
Cognitive Neuroscience Unit, School of Psychology, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia.
Deakin Child Study Centre, School of Psychology, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia.
Neurosci Biobehav Rev. 2015 Aug;55:547-72. doi: 10.1016/j.neubiorev.2015.05.017. Epub 2015 Jun 12.
Imaging and lesion studies have suggested numerous roles for the temporoparietal junction (TPJ), for example in attention and neglect, social cognition, and self/other processing. These studies cannot establish causal relationships, and the importance and relevance of (and interrelationships between) proposed roles remain controversial. This review examined studies that use noninvasive transcranial stimulation (NTS) to explore TPJ function. Of the 459 studies identified, 40 met selection criteria. The strengths and weaknesses of NTS-relevant parameters used are discussed, and methodological improvements suggested. These include the need for careful selection of stimulation sites and experimental tasks, and use of neuronavigation and concurrent functional activity measures. Without such improvements, overlapping and discrete functions of the TPJ will be difficult to disentangle. Nevertheless, the contributions of these studies to theoretical models of TPJ function are discussed, and the clinical relevance of TPJ stimulation explored. Some evidence exists for TPJ stimulation in the treatment of auditory hallucinations, tinnitus, and depersonalisation disorder. Further examination of the TPJ in conditions such as autism spectrum disorder is also warranted.
影像学和病灶研究表明颞顶联合区（TPJ）具有多种功能，例如在注意力和忽视、社会认知以及自我/他人加工方面。这些研究无法建立因果关系，并且所提出的功能的重要性、相关性（以及它们之间的相互关系）仍存在争议。本综述考察了使用非侵入性经颅刺激（NTS）来探究TPJ功能的研究。在检索到的459项研究中，有40项符合入选标准。文中讨论了所使用的与NTS相关参数的优缺点，并提出了方法学上的改进建议。这些建议包括需要仔细选择刺激部位和实验任务，以及使用神经导航和同步功能活动测量。如果没有这些改进，TPJ的重叠和离散功能将难以区分。尽管如此，文中还是讨论了这些研究对TPJ功能理论模型的贡献，并探讨了TPJ刺激的临床相关性。有证据表明TPJ刺激可用于治疗幻听、耳鸣和人格解体障碍。对于自闭症谱系障碍等病症中TPJ的进一步研究也很有必要。
