Bryne M, Koppang H S, Lilleng R, Stene T, Bang G, Dabelsteen E
Department of Oral Pathology, Oslo University, Blindern, Norway.
J Oral Pathol Med. 1989 Sep;18(8):432-7. doi: 10.1111/j.1600-0714.1989.tb01339.x.
The prognostic value of histopathologic grading of oral squamous cell carcinomas (SCC) has varied from not any to highly significant. We have retrospectively studied all (130) SCCs registered in Norway 1963-72 in the buccal and maxillary alveolar mucosa. From 68 of these cases biopsy specimens of acceptable quality were obtained. Broders' method of grading was compared with a modification of a recent malignancy grading system recommended by Anneroth et al. which was performed only within the histologically most invasive areas of the tumors. Cox's multivariate survival analyses showed that this grading in the invasive sites had highly significant prognostic value. Broders grade had no prognostic value. The stage of tumor had also prognostic value. These highly significant results indicate that the histologically invasive areas may be primarily responsible for the clinical behavior of the tumor, and this may be of importance for the choice of therapy for oral SCC.
口腔鳞状细胞癌（SCC）组织病理学分级的预后价值各不相同，从无到高度显著。我们回顾性研究了1963年至1972年在挪威登记的所有（130例）颊部和上颌牙槽黏膜的SCC。从其中68例病例中获取了质量合格的活检标本。将布罗德斯分级方法与安妮罗思等人推荐的一种近期恶性肿瘤分级系统的改良方法进行了比较，后者仅在肿瘤组织学上浸润最深的区域进行。考克斯多变量生存分析表明，这种在浸润部位的分级具有高度显著的预后价值。布罗德斯分级没有预后价值。肿瘤分期也具有预后价值。这些高度显著的结果表明，组织学浸润区域可能是肿瘤临床行为的主要决定因素，这对于口腔SCC的治疗选择可能具有重要意义。
