Lin B L, Iwata Y
Department of Obstetrics and Gynecology, Kawasaki Municipal Hospital.
Jpn J Antibiot. 1989 Oct;42(10):2082-9.
Pharmacokinetic and clinical studies on cefodizime (THR-221, CDZM) were carried out and the following results were obtained. Concentrations of CDZM in serum and uterine tissues were determined from 38 to 282 minutes after drip infusion of 1 g CDZM. CDZM reached peak level of 25.0 micrograms/g or higher in each tissue during a period of 38 to 83 minutes. Concentrations of CDZM in the dead space exudate after drip infusion of 2 g CDZM were also studied. At 240 minutes after injection, CDZM concentration in exudate reached a peak of 46.88 micrograms/ml. These levels far exceeded MICs of CDZM against major pathogens most often isolated in the field of obstetrics and gynecology. CDZM was administered to 7 patients with their diseases diagnosed as pelvic peritonitis (4 cases) or acute adnexitis (3 cases) at a dose of 2-4 g per day for 6-14. days. Clinical response was good in all cases. Transient elevation of liver function was noticed in 2 cases. No other adverse reactions were noted during the study.
对头孢地嗪（THR - 221，CDZM）进行了药代动力学和临床研究，并获得了以下结果。在静脉滴注1g CDZM后的38至282分钟内测定血清和子宫组织中CDZM的浓度。在38至83分钟期间，CDZM在每个组织中达到25.0微克/克或更高的峰值水平。还研究了静脉滴注2g CDZM后死腔渗出液中CDZM的浓度。注射后240分钟，渗出液中CDZM浓度达到峰值46.88微克/毫升。这些水平远远超过了CDZM对妇产科领域最常分离的主要病原体的最低抑菌浓度。对7例诊断为盆腔腹膜炎（4例）或急性附件炎（3例）的患者给予CDZM，剂量为每天2 - 4g，持续6 - 14天。所有病例临床反应良好。2例患者出现肝功能短暂升高。研究期间未发现其他不良反应。
