13价肺炎球菌结合疫苗预防成人肺炎球菌肺炎：CAPiTA，成人社区获得性肺炎免疫试验
Prevention of adult pneumococcal pneumonia with the 13-valent pneumococcal conjugate vaccine: CAPiTA, the community-acquired pneumonia immunization trial in adults.
作者信息
Isturiz Raul, Webber Chris
机构信息
a Pfizer Vaccine Research ; Collegeville , PA , USA.
出版信息
Hum Vaccin Immunother. 2015;11(7):1825-7. doi: 10.1080/21645515.2015.1043502.
Abstract
The aging of the world population is expected to be accompanied by increased pneumococcal pneumonia in older adults. To address this, the Community-Acquired Pneumonia immunization Trial in Adults (CAPiTA), a large, randomized, placebo-controlled trial conducted to assess the 13-valent pneumococcal conjugate vaccine (PCV13) in adults ≥ 65 years, found statistically significant vaccine efficacy for first episodes of vaccine-type community-acquired pneumonia (VT-CAP; 46%), nonbacteremic/noninvasive VT-CAP (45%), and VT invasive pneumococcal disease (75%), along with an acceptable safety profile. Study results were presented to the US Advisory Committee on Immunization Practices in June 2014, which subsequently recommended sequential PCV13 and 23-valent pneumococcal polysaccharide vaccination for adults ≥ 65 years. Thus, appropriate protection of adults at risk for pneumococcal CAP will include vaccination with PCV13.
摘要
预计全球人口老龄化将伴随着老年成人肺炎球菌肺炎发病率的上升。为应对这一情况，开展了成人社区获得性肺炎免疫试验（CAPiTA），这是一项大型随机安慰剂对照试验，旨在评估13价肺炎球菌结合疫苗（PCV13）在65岁及以上成人中的效果，结果发现该疫苗对疫苗型社区获得性肺炎（VT-CAP；46%）、非菌血症/非侵袭性VT-CAP（45%）和VT侵袭性肺炎球菌病（75%）的首发病例具有统计学显著的疫苗效力，且安全性良好。研究结果于2014年6月提交给美国免疫实践咨询委员会，该委员会随后建议65岁及以上成人先后接种PCV13和23价肺炎球菌多糖疫苗。因此，对有肺炎球菌社区获得性肺炎风险的成人进行适当保护将包括接种PCV13。
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