Liu Shizhou, Tong Mengchao, Yu Yang, Xie Hexin, Li Hao, Wang Wei
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology, 130 Mei-long Road, Shanghai 200237, China.
Chem Commun (Camb). 2015 Jun 30;51(56):11221-4. doi: 10.1039/c5cc03562g.
A chiral amine catalyzed enantioselective α-functionalization of α-substituted β-ketocarbonyls with electron-deficient vinylarenes has been developed to construct the dicarbonyl products with the formation of a chiral all-carbon quaternary stereocenter. The products can be used for the efficient synthesis of useful but challenging chiral quaternary centered pyrazolones.
已开发出一种手性胺催化的α-取代β-酮羰基与缺电子乙烯基芳烃的对映选择性α-官能化反应，以构建具有手性全碳季碳立体中心的二羰基产物。这些产物可用于高效合成有用但具有挑战性的手性季碳中心吡唑啉酮。
