Arufe-Martinez M I, Romero-Palanco J L, Gamero-Lucas J, Vizcaya-Rojas M A
Departamento de Medicina Legal y Toxicologia, Facultad de Medicina, Cádiz, Spain.
J Anal Toxicol. 1989 Nov-Dec;13(6):337-53. doi: 10.1093/jat/13.6.337.
Part I. Cocaine-Lidocaine Mixtures A rapid procedure based on second-derivative UV spectrophotometry is proposed for the simultaneous determination of cocaine and lidocaine. The optimum magnitudes are chosen in terms of response linearity, sensitivity, relative percent error, relative recovery data, and reproducibility. Part II. Cocaine-Procaine Mixtures A derivative spectrophotometric method based on second-derivative ultraviolet absorption spectra has been developed for the simultaneous determination of cocaine and procaine. Several derivative magnitudes have been investigated. A statistical analysis of the results is reported. Part III. Cocaine-Tetracaine Mixtures A simple method has been developed for the simultaneous determination of cocaine and tetracaine by measuring the amplitudes of the positive peak at 286.6 nm and the negative peak at 313.9 nm with respect to zero baseline. Part IV. Cocaine-Benzocaine Mixtures Derivative ultraviolet spectrophotometry has been used for the simultaneous determination of cocaine and benzocaine. Both cocaine and benzocaine can be assayed by measurement of, respectively, the peak-to-peak amplitude D261.4,277.4 and the peak-to-zero amplitude D299.4. The method is applied to simulated street samples of cocaine.
第一部分. 可卡因 - 利多卡因混合物
提出了一种基于二阶导数紫外分光光度法的快速程序，用于同时测定可卡因和利多卡因。根据响应线性、灵敏度、相对百分误差、相对回收率数据和重现性选择最佳参数。
第二部分. 可卡因 - 普鲁卡因混合物
已开发出一种基于二阶导数紫外吸收光谱的导数分光光度法，用于同时测定可卡因和普鲁卡因。研究了几个导数参数。报告了结果的统计分析。
第三部分. 可卡因 - 丁卡因混合物
已开发出一种简单方法，通过测量相对于零基线在286.6 nm处的正峰和在313.9 nm处的负峰的幅度来同时测定可卡因和丁卡因。
第四部分. 可卡因 - 苯佐卡因混合物
导数紫外分光光度法已用于同时测定可卡因和苯佐卡因。可卡因和苯佐卡因均可分别通过测量峰 - 峰幅度D261.4,277.4和峰 - 零幅度D299.4进行测定。该方法应用于模拟的可卡因街头样品。
