Sierra J, Grañena A, Martí J M, Carreras E, García J, Valls A, Martínez E, Puntí C, Martí-Carvajal A, Rozman C
Med Clin (Barc). 1989 Oct 14;93(11):401-5.
The results of bone marrow autograft (BMAG) in 20 patients with acute leukemia (AL) consecutively treated from October 1985 and May 1988 are reported. The follow up was continued until November 1988. The mean age of the patients was 20 years (range 10-48) and their diagnoses were acute myeloblastic leukemia (AML) in 12 and acute lymphoblastic leukemia (ALL) in 8. The preparation for BMAG included cyclophosphamide and whole body radiation in all cases. The procedure was carried out in the first complete remission (CR-1) in 5 patients, in CR-2 in 11, in CR-3 in 2, and in CR-4 in another 2. Two patients died as a direct consequence of BMAG, 11 relapsed and 7 are alive and free from relapse. The likelihood of survival free from prolonged illness was calculated as 24% for the whole series, 60% for the cases of BMAG in CR-1 and 50% for the group of patients with AML. The results were poor in the cases of BMAG carried out for AL in an advanced stage. On the basis of these results the experience of other authors with this therapeutic modality is reviewed, and its current indications are discussed.
报告了1985年10月至1988年5月连续治疗的20例急性白血病（AL）患者进行骨髓自体移植（BMAG）的结果。随访持续至1988年11月。患者的平均年龄为20岁（范围10 - 48岁），其中12例诊断为急性髓细胞白血病（AML），8例为急性淋巴细胞白血病（ALL）。所有病例的BMAG预处理均包括环磷酰胺和全身放疗。该操作在5例患者的首次完全缓解期（CR - 1）、11例患者的CR - 2期、2例患者的CR - 3期以及另外2例患者的CR - 4期进行。2例患者因BMAG直接死亡，11例复发，7例存活且无复发。整个系列无长期疾病存活的可能性计算为24%，CR - 1期进行BMAG的病例为60%，AML患者组为50%。晚期AL进行BMAG的病例结果较差。基于这些结果，回顾了其他作者使用这种治疗方式的经验，并讨论了其当前适应证。
