Vilhena Cristina, Gameiro Cátia, Tomás Cláudia, Santos Antónia, Ilgenfritz Raquel
Department of Obstetrics and Gynecology, Garcia de Orta Hospital, Avenida Torrado da Silva, 2801-951 Almada, Portugal.
Department of Anatomical Pathology, Garcia de Orta Hospital, Avenida Torrado da Silva, 2801-951 Almada, Portugal.
Case Rep Obstet Gynecol. 2015;2015:987940. doi: 10.1155/2015/987940. Epub 2015 May 20.
Fetal warfarin syndrome is a consequence of maternal intake of warfarin during pregnancy and comprises a wide range of manifestations, including some typical facial dysmorphologic features. The authors report a case of prenatal ultrasonographic diagnosis of warfarin embryopathy in an obese woman on unsupervised warfarin prophylaxis at the 16th week of gestation. The fetus presented with facial dysmorphism, pectus excavatum, diaphragmatic hernia, and pulmonary hypoplasia. To the best of our knowledge, this is the second reported case of warfarin-associated diaphragmatic hernia.
胎儿华法林综合征是孕期母亲服用华法林的后果,包括一系列表现,其中有一些典型的面部畸形特征。作者报告了一例肥胖女性在妊娠第16周未经监测的华法林预防治疗期间,产前超声诊断为华法林胚胎病的病例。胎儿表现为面部畸形、漏斗胸、膈疝和肺发育不全。据我们所知,这是第二例报告的与华法林相关的膈疝病例。