Department of Pediatrics, UCMS and GTB Hospital, Dilshad Garden, Delhi, India.
Arch Gynecol Obstet. 2010 Sep;282(3):335-7. doi: 10.1007/s00404-010-1369-5. Epub 2010 Jan 29.
Fetal warfarin syndrome (warfarin embryopathy) is a consequence of maternal ingestion of warfarin during pregnancy. Warfarin fetotoxicity comprises wide range of manifestations including dysmorphology in neonate with characteristic classical features of nasal hypoplasia and stippling of epiphyses.
Here we present a case of a neonate whose mother was on unsupervised warfarin prophylaxis throughout pregnancy. A brief review of literature with suitable options for anticoagulation during pregnancy is discussed.
The final consensus over LMWH and warfarin in the first trimester is yet to be finalised. The treatment of warfarin embryopathy is symptomatic. Long term sequels in survivors are still not known.
胎儿华法林综合征（华法林胚胎病）是母亲在怀孕期间服用华法林的后果。华法林的胎儿毒性表现范围广泛，包括新生儿出现畸形，具有特征性的典型特征，包括鼻发育不全和骨骺点状。
在这里，我们介绍了一个新生儿的病例，其母亲在整个怀孕期间接受了未经监督的华法林预防治疗。简要回顾了文献，并讨论了怀孕期间适当的抗凝选择。
在头三个月，低分子肝素和华法林的最终共识尚未最终确定。华法林胚胎病的治疗是对症的。幸存者的长期后果仍不清楚。
