Branch Leslie G, Albertini John G, Leshin Barry
*Department of Plastic and Reconstructive Surgery, Wake Forest Baptist Health, Winston-Salem †The Skin Surgery Center, Winston-Salem, NC.
J Craniofac Surg. 2015 Jun;26(4):e322-3. doi: 10.1097/SCS.0000000000001550.
Atypical fibroxanthoma (AFX) has been characterized variously as a benign noninvasive neoplasm with rare recurrence. We report 2 cases of recurrent AFX. There is ongoing controversy over the diagnosis of AFX versus malignant fibrous histiocytoma (MFH) in the clinical context of recurrent AFX. Histopathologic diagnosis of fibrohistiocytic neoplasms can be quite challenging and small foci of cancer can be easily overlooked. This is particularly problematic when scarring associated with recurrent tumors is present. The utility of en face sections, as utilized in Mohs micrographical surgery, and the employment of immunohistochemical stains may be helpful in diagnosis. Recurrence of AFX can occur but is difficult to distinguish from MFH.
非典型纤维黄色瘤（AFX）一直被描述为一种良性非侵袭性肿瘤，复发罕见。我们报告2例复发性AFX。在复发性AFX的临床背景下，关于AFX与恶性纤维组织细胞瘤（MFH）的诊断存在持续争议。纤维组织细胞肿瘤的组织病理学诊断可能极具挑战性，癌的小病灶很容易被忽视。当存在与复发性肿瘤相关的瘢痕形成时，这一问题尤为突出。在莫氏显微外科手术中使用的表面切片的效用以及免疫组织化学染色的应用可能有助于诊断。AFX可复发，但难以与MFH区分。
