Epand Richard M, Bach Diana, Wachtel Ellen
Department of Biochemistry and Biomedical Sciences, McMaster University Health Sciences Centre, Hamilton, Canada.
Soft Matter. 2015 Jul 21;11(27):5580-1; discussion 5582-4. doi: 10.1039/c4sm02819h.
In a recent article, Garg et al. used neutron scattering techniques to determine the limiting amount of cholesterol which vesicles of either POPS or POPC can accommodate. This amount was called "the cholesterol solubility limit". In light of extensive literature on cholesterol phase separation in phospholipid bilayers, the way in which "solubility limit" is defined in this article and the conclusions derived are misleading and require some clarification.
在最近的一篇文章中，加尔格等人使用中子散射技术来确定POPS或POPC囊泡能够容纳的胆固醇极限量。这个量被称为“胆固醇溶解度极限”。鉴于关于磷脂双层中胆固醇相分离的大量文献，本文中“溶解度极限”的定义方式以及由此得出的结论具有误导性，需要一些澄清。
