Auger P, Colin P, Joly J, Poirier S, Colin D
Mycoses. 1989 Sep;32(9):455-60.
This article describes the in vivo evaluation of a new topical preparation (Zincostatin) indicated for Candida albicans infected diaper rash. In order to study the influence of the 20% zinc oxide (W/W) (a protectant) on the anti-candidal efficacy of the 100,000 U/g of nystatin found in the ointment, groups of guinea pigs received different treatments with or without local occlusion. Zinc oxide, nystatin, or the combination of both were applied, in the ointment base, on the backs of the animals inoculated with a fresh strain of Candida albicans. Macroscopic and microbiological evaluation of the skin lesions were assessed at regular intervals during 21 days. While the two treatments containing nystatin were more effective than zinc oxide alone, the latter agent did not decrease the efficacy of the antifungal drug in combination therapy. Also, zinc oxide seemed to afford some protection against local maceration induced by occlusion, which increased the severity of the infection.
本文描述了一种用于治疗白色念珠菌感染所致尿布疹的新型局部制剂（制霉菌素锌）的体内评估。为了研究20%氧化锌（重量/重量）（一种保护剂）对软膏中每克含10万单位制霉菌素的抗念珠菌疗效的影响，几组豚鼠接受了有无局部封闭的不同治疗。将氧化锌、制霉菌素或两者的组合以软膏基质形式涂于接种了白色念珠菌新鲜菌株的动物背部。在21天内定期对皮肤损伤进行宏观和微生物学评估。虽然两种含制霉菌素的治疗比单独使用氧化锌更有效，但后者在联合治疗中并未降低抗真菌药物的疗效。此外，氧化锌似乎能为封闭引起的局部浸渍提供一定保护，封闭会增加感染的严重程度。
