腹腔镜Nissen胃底折叠术后的体重指数和胃饥饿素水平
Body mass index and ghrelin levels after laparoscopic Nissen fundoplication.
作者信息
Yigit Taner, Coskun Ali Kagan, Harlak Ali, Sinan Huseyin, Unlu Aytekin, Tapan Serkan, Lapsekili Emin, Kozak Orhan
机构信息
Department of Surgery, Gulhane Military Medical Academy, Ankara, Turkey.
出版信息
Langenbecks Arch Surg. 2015 Jul;400(5):585-8. doi: 10.1007/s00423-015-1315-x. Epub 2015 Jun 18.
PURPOSE
The study aims to evaluate the changes between body mass index (BMI) and ghrelin levels after laparoscopic Nissen fundoplication (LNF).
METHODS
Twenty-four consecutive patients with gastroesophageal reflux disease who were scheduled for LNF consented to participate in the study. The participants' age, sex, preoperative (phase 0), postoperative 1st week (phase 1) and postoperative 4th week (phase 2) dysphagia scores, plasma ghrelin levels, and BMI were recorded.
RESULTS
Compared to the preoperative level (phase 0), ghrelin was decreased in both phase 1 and phase 2. A strong correlation in the changes in the ghrelin values and BMI between phase 0 and phase 2 was detected. There was a strong, statistically significant difference in the changes in the BMI values between phase 1 and phase 2.
CONCLUSIONS
Total plication of the fundus impairs its ghrelin-secreting functions for up to 4 weeks and is accompanied by weight loss.
目的
本研究旨在评估腹腔镜Nissen胃底折叠术（LNF）后体重指数（BMI）和胃饥饿素水平的变化。
方法
连续24例计划接受LNF的胃食管反流病患者同意参与本研究。记录参与者的年龄、性别、术前（0期）、术后第1周（1期）和术后第4周（2期）的吞咽困难评分、血浆胃饥饿素水平和BMI。
结果
与术前水平（0期）相比，1期和2期的胃饥饿素均降低。检测到0期和2期胃饥饿素值和BMI变化之间存在强相关性。1期和2期BMI值的变化存在强烈的、统计学上显著的差异。
结论
胃底完全折叠会损害其胃饥饿素分泌功能长达4周，并伴有体重减轻。
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