Department of Minimally Invasive, Hernia and Abdominal Surgery, People's Hospital of Xinjiang Autonomous Region, Urumqi, Xinjiang Uygur Autonomous Region, 830011, China.
Graduate School, Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, 830054, China.
BMC Surg. 2024 Jun 5;24(1):176. doi: 10.1186/s12893-024-02468-2.
Laparoscopic sleeve gastrectomy combined with fundoplication (LSGFD) can significantly control body weight and achieve effective anti-reflux effects. The aim of this study is to investigate the correlation between the alteration in Ghrelin levels and weight loss following SGFD, and to compare Ghrelin levels, weight loss and metabolic improvements between SG and SGFD, with the objective of contributing to the existing body of knowledge on SGFD technique in the management of patients with obesity and gastroesophageal reflux disease (GERD).
A retrospective analysis was conducted on the clinical data of 115 obese patients who underwent bariatric surgery between March 2023 and June 2023 at the Department of Minimally Invasivew Surgery, Hernia and Abdominal Wall Surgery, People's Hospital of Xinjiang Uygur Autonomous Region. The subjects were divided into two groups based on surgical methods: sleeve gastrectomy group (SG group, 93 cases) and sleeve gastrectomy combined with fundoplication group (SGFD group, 22 cases). Clinical data, such as ghrelin levels before and after the operation, were compared between the two groups, and the correlation between changes in ghrelin levels and weight loss effectiveness after the operation was analyzed.
Three months after the operation, there was no significant difference in body mass, BMI, EWL%, fasting blood glucose, triglyceride, cholesterol, and uric acid levels between the SG and SGFD groups (P > 0.05). However, the SGFD group exhibited a significant decrease in body weight, BMI, and uric acid levels compared to preoperative levels (P < 0.05), while the decrease in ghrelin levels was not statistically significant (P > 0.05). Logistic regression analysis indicated that ghrelin levels three months after the operation were influential in postoperative weight loss.
The reduction of plasma Ghrelin level in patients after SGFD is not as obvious as that in patients after SG, but it can make obese patients get the same good weight loss and metabolic improvement as patients after SG. Ghrelin level at the third month after operation is the influencing factor of postoperative weight loss.
腹腔镜袖状胃切除术联合胃底折叠术（LSGFD）可显著控制体重，实现有效的抗反流效果。本研究旨在探讨 SGFD 术后 Ghrelin 水平的变化与体重减轻之间的相关性，并比较 SG 和 SGFD 之间的 Ghrelin 水平、体重减轻和代谢改善，以期为 SGFD 技术在肥胖和胃食管反流病（GERD）患者管理中的应用提供参考。
回顾性分析 2023 年 3 月至 2023 年 6 月在新疆维吾尔自治区人民医院微创、疝与腹壁外科行减重手术的 115 例肥胖患者的临床资料，根据手术方式分为袖状胃切除术组（SG 组，93 例）和袖状胃切除术联合胃底折叠术组（SGFD 组，22 例）。比较两组患者手术前后 Ghrelin 水平等临床资料，并分析术后 Ghrelin 水平变化与体重减轻效果的相关性。
术后 3 个月，SG 组与 SGFD 组患者的体质量、BMI、EWL%、空腹血糖、甘油三酯、胆固醇、尿酸水平比较，差异均无统计学意义（P>0.05）；SGFD 组患者的体质量、BMI 及尿酸水平较术前降低，差异有统计学意义（P<0.05），而 Ghrelin 水平较术前差异无统计学意义（P>0.05）。Logistic 回归分析显示，术后 3 个月 Ghrelin 水平是影响术后体重减轻的因素。
SGFD 术后患者血浆 Ghrelin 水平的降低不如 SG 术后明显，但仍能使肥胖患者获得与 SG 术后相同的良好体重减轻和代谢改善效果。术后 3 个月 Ghrelin 水平是影响术后体重减轻的因素。
