Weintraub Lauren, Driscoll Catherine, Aydin Scott, Lamour Jaqueline M, Weinstein Sam, Manwani Deepa
Division of Hematology/Oncology, Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.
Division of Cardiology, Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.
Pediatr Transplant. 2015 Sep;19(6):E152-6. doi: 10.1111/petr.12540. Epub 2015 Jun 18.
HIT presents the clinician with unique diagnostic challenges, especially in the pediatric population. The HIT clinical sequelae of thrombocytopenia and thrombosis are secondary to the activation of platelets by heparin-antibody complexes. Diagnosis involves clinical observations and confirmatory laboratory testing using antibody detection and the functional SRA. As we describe in the following case of a six-yr-old female, the SRA may be difficult to interpret in the case of high-titer antibodies and illustrates the need for repeat testing in cases of high clinical suspicion.
肝素诱导的血小板减少症（HIT）给临床医生带来了独特的诊断挑战，尤其是在儿科人群中。血小板减少症和血栓形成的HIT临床后遗症是肝素-抗体复合物激活血小板的继发结果。诊断包括临床观察以及使用抗体检测和功能性血清素释放测定（SRA）进行的实验室确诊检测。正如我们在以下一名6岁女性的病例中所描述的，在高滴度抗体的情况下，SRA可能难以解释，这说明了在临床高度怀疑的病例中需要重复检测。
