间充质干细胞衰老：机制及其对骨骼和非骨骼组织的影响
Mesenchymal stem cell aging: Mechanisms and influences on skeletal and non-skeletal tissues.
作者信息
Liu Huijuan, Xia Xuechun, Li Baojie
机构信息
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China.
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China
出版信息
Exp Biol Med (Maywood). 2015 Aug;240(8):1099-106. doi: 10.1177/1535370215591828. Epub 2015 Jun 18.
The aging population and the incidence of aging-related diseases such as osteoporosis are on the rise. Aging at the tissue and organ levels usually involves tissue stem cells. Human and animal model studies indicate that aging affects two aspects of mesenchymal stem cell (MSC): a decrease in the bone marrow MSC pool and biased differentiation into adipocyte at the cost of osteoblast, which underlie the etiology of osteoporosis. Aging of MSC cells is also detrimental to some non-skeletal tissues, in particular the hematopoietic system, where MSCs serve as a niche component. In addition, aging compromises the therapeutic potentials of MSC cells, including cells isolated from aged individuals or cells cultured for many passages. Here we discuss the recent progress on our understanding of MSC aging, with a focus on the effects of MSC aging on bone remodeling and hematopoiesis and the mechanisms of MSC aging.
老龄化人口以及诸如骨质疏松症等与衰老相关疾病的发病率正在上升。组织和器官层面的衰老通常涉及组织干细胞。人类和动物模型研究表明，衰老影响间充质干细胞（MSC）的两个方面：骨髓MSC库减少，且以成骨细胞为代价偏向分化为脂肪细胞，这是骨质疏松症病因的基础。MSC细胞的衰老对一些非骨骼组织也有害，尤其是造血系统，其中MSC作为一种微环境成分。此外，衰老会损害MSC细胞的治疗潜力，包括从老年个体分离的细胞或传代培养许多次的细胞。在这里，我们讨论了我们对MSC衰老理解的最新进展，重点是MSC衰老对骨重塑和造血的影响以及MSC衰老的机制。
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