硝酸镓对患有炎症性病变的大鼠体内67镓分布的影响。

Effect of gallium nitrate on the in vivo distribution of 67Ga in rats bearing inflammatory lesions.

作者信息

Kohno H, Kanayama S, Ohkubo Y, Kubodera A

机构信息

Department of Radiopharmacy, Tohoku College of Pharmacy, Sendai-shi, Japan.

出版信息

Radioisotopes. 1989 Jul;38(7):311-4. doi: 10.3769/radioisotopes.38.7_311.

DOI:10.3769/radioisotopes.38.7_311

PMID:2608928

Abstract

Effect of gallium nitrate on the pharmacokinetics and tissue accumulation of 67Ga was investigated in rats bearing turpentine oil-induced abscess. Gallium nitrate accelerated the blood disappearance of 67Ga, but this effect was less potent than that of ferric nitrate. The accumulation of 67Ga in liver was significantly lowered by gallium nitrate, but no significant decrease of 67Ga accumulation in abscess was observed. On the other hand, 67Ga accumulation in bone was slightly facilitated by gallium nitrate. Ferric nitrate exerted a similar effect on tissue accumulation of 67Ga as gallium nitrate.

摘要

在患有松节油诱导脓肿的大鼠中研究了硝酸镓对67Ga药代动力学和组织蓄积的影响。硝酸镓加速了67Ga的血液清除，但其作用比硝酸铁弱。硝酸镓显著降低了67Ga在肝脏中的蓄积，但未观察到脓肿中67Ga蓄积的显著减少。另一方面，硝酸镓略微促进了67Ga在骨骼中的蓄积。硝酸铁对67Ga组织蓄积的影响与硝酸镓相似。