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脐带血移植联合间充质干细胞输注治疗一名青少年重型再生障碍性贫血患者：病例报告及文献复习

Umbilical cord blood transplantation supplemented with the infusion of mesenchymal stem cell for an adolescent patient with severe aplastic anemia: a case report and review of literature.

作者信息

Luan Chengxin, Chen Runzhe, Chen Baoan, Ding Jiahua, Ni Ming

机构信息

Department of Hematology and Oncology (Key Department of Jiangsu Medicine), Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province, People's Republic of China.

出版信息

Patient Prefer Adherence. 2015 Jun 11;9:759-65. doi: 10.2147/PPA.S81509. eCollection 2015.

DOI:10.2147/PPA.S81509
PMID:26089653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4468992/
Abstract

Delayed hematopoietic recovery and increased rate of engraftment failure limit the use of umbilical cord blood transplantation (UCBT). We describe a case of severe aplastic anemia treated by UCBT combined with mesenchymal stem cells. Our case reveals that infusing mesenchymal stem cells early (about 40 days) after UCBT may promote hematopoietic recovery. This experience will guide clinical scientists, especially hematologists, to deal with similar situations and encourage them to widen this strategy.

摘要

延迟的造血恢复和移植失败率增加限制了脐带血移植（UCBT）的应用。我们描述了一例采用UCBT联合间充质干细胞治疗的重型再生障碍性贫血病例。我们的病例显示，在UCBT后早期（约40天）输注间充质干细胞可能促进造血恢复。这一经验将指导临床科学家，尤其是血液学家，处理类似情况，并鼓励他们推广这一策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a610/4468992/dc7f1edce9a7/ppa-9-759Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a610/4468992/b6784d93734f/ppa-9-759Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a610/4468992/01039b91eafb/ppa-9-759Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a610/4468992/7492f3a36eef/ppa-9-759Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a610/4468992/dc7f1edce9a7/ppa-9-759Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a610/4468992/b6784d93734f/ppa-9-759Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a610/4468992/01039b91eafb/ppa-9-759Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a610/4468992/7492f3a36eef/ppa-9-759Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a610/4468992/dc7f1edce9a7/ppa-9-759Fig4.jpg

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本文引用的文献

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