组胺能结节性乳头体核神经元在多系统萎缩和路易体痴呆中的缺失。
Histaminergic tuberomammillary neuron loss in multiple system atrophy and dementia with Lewy bodies.
机构信息
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Division of Anatomical Pathology, Mayo Clinic, Rochester, Minnesota, USA.
出版信息
Mov Disord. 2015 Jul;30(8):1133-9. doi: 10.1002/mds.26287. Epub 2015 Jun 22.
BACKGROUND
Histaminergic neurons of the tuberomammillary nucleus are critical for maintenance of wakefulness and participate in basal ganglia modulation and sympathoexcitation. All of these functions are affected in multiple system atrophy and dementia with Lewy bodies.
OBJECTIVES
To determine the involvement of histaminergic neurons in these synucleinopathies.
METHODS
Immunocytochemical staining for histidine decarboxylase and stereological cell counts in the posterolateral hypothalamus from six cases with multiple system atrophy, six with dementia with Lewy bodies, and five healthy controls.
RESULTS
Compared with healthy controls, significant reduction of histaminergic neurons was found both in multiple system atrophy (total estimated cell count, 94,677 ± 5,521 vs. 169,579 ± 12,443; P < 0.001) and in dementia with Lewy bodies (91,110 ± 13,021 vs. 169,579 ± 12,443; P < 0.001).
CONCLUSIONS
Loss of tuberomammillary histaminergic neurons could potentially contribute to motor, sleep, and autonomic manifestations of both multiple system atrophy and dementia with Lewy bodies.
背景
结节乳头核的组胺能神经元对于维持觉醒状态至关重要，并且参与基底节调制和交感神经兴奋。这些功能在多系统萎缩和路易体痴呆中均受到影响。
目的
确定组胺能神经元在这些突触核蛋白病中的作用。
方法
对 6 例多系统萎缩、6 例路易体痴呆和 5 例健康对照者的下丘脑后外侧区进行组氨酸脱羧酶免疫细胞化学染色和立体学细胞计数。
结果
与健康对照组相比，多系统萎缩症（总估计细胞数为 94677±5521 个 vs. 169579±12443 个；P<0.001）和路易体痴呆症（91110±13021 个 vs. 169579±12443 个；P<0.001）患者的组胺能神经元数量均显著减少。
结论
结节乳头核组胺能神经元的丧失可能导致多系统萎缩症和路易体痴呆症的运动、睡眠和自主神经表现。
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