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基层医疗中出现关节疼痛的儿童。

The child with joint pain in primary care.

作者信息

Sen E S, Clarke S L N, Ramanan A V

机构信息

Department of Paediatric Rheumatology, Bristol Royal Hospital for Children, Bristol, UK; School of Clinical Sciences, University of Bristol, Bristol, UK.

Department of Paediatric Rheumatology, Bristol Royal Hospital for Children, Bristol, UK.

出版信息

Best Pract Res Clin Rheumatol. 2014 Dec;28(6):888-906. doi: 10.1016/j.berh.2015.04.008. Epub 2015 May 23.

Abstract

Joint pains are a common reason for children to present to primary care. The differential diagnosis is large including some diseases that do not primarily affect the musculoskeletal system. Although the cause for many patients will be benign and self-resolving, in rare cases the diagnosis is associated with long-term morbidity and mortality if not detected early and appropriately treated. These include primary and secondary malignancies, septic arthritis, osteomyelitis, inflammatory arthritis, slipped upper femoral epiphysis (SUFE) and non-accidental injury. We highlight the importance of a thorough history and directed yet comprehensive examination. A diagnostic algorithm is provided to direct primary care physicians' clinical assessment and investigation with the evidence base where available. In many cases, tests are not required, but if there is suspicion of malignancy, infection or inflammatory conditions, laboratory tests including full blood count, blood film, erythrocyte sedimentation rate, C-reactive protein and lactate dehydrogenase help to support or exclude the diagnosis. Autoimmune tests, such as antinuclear antibodies and rheumatoid factor, have no diagnostic role in juvenile idiopathic arthritis; therefore, we advise against any form of 'rheumatological/autoimmune disease screen' in primary care. Imaging does have a place in the diagnosis of joint pains in children, with plain radiographs being most appropriate for suspected fractures and SUFE, whilst ultrasound is better for the detection of inflammatory or infective effusions. The appropriate referral of children to paediatric rheumatologists, oncologists, orthopaedic surgeons and the emergency department are discussed.

摘要

关节疼痛是儿童到基层医疗就诊的常见原因。鉴别诊断范围广泛,包括一些并非主要影响肌肉骨骼系统的疾病。尽管许多患者的病因是良性的且可自行缓解,但在极少数情况下,如果未能早期发现并得到适当治疗,诊断结果可能与长期的发病率和死亡率相关。这些情况包括原发性和继发性恶性肿瘤、化脓性关节炎、骨髓炎、炎性关节炎、股骨头骨骺滑脱(SUFE)和非意外伤害。我们强调全面病史和有针对性且全面检查的重要性。本文提供了一种诊断算法,以指导基层医疗医生在有可用证据的情况下进行临床评估和调查。在许多情况下,并不需要进行检查,但如果怀疑有恶性肿瘤、感染或炎症性疾病,包括全血细胞计数、血涂片、红细胞沉降率、C反应蛋白和乳酸脱氢酶在内的实验室检查有助于支持或排除诊断。自身抗体检测,如抗核抗体和类风湿因子,在幼年特发性关节炎中没有诊断作用;因此,我们建议在基层医疗中不要进行任何形式的“风湿性/自身免疫性疾病筛查”。影像学检查在儿童关节疼痛的诊断中确实有一定作用,普通X线片最适合疑似骨折和SUFE的情况,而超声更有利于检测炎性或感染性积液。本文还讨论了将儿童适当转诊给儿科风湿病学家、肿瘤学家、骨科医生和急诊科的相关问题。

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