Mifsud Edin Jessica, Tan Amabel C L, Brown Lorena Elizabeth, Chua Brendon Yew Loong, Jackson David C
Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne , Parkville, VIC , Australia.
Front Immunol. 2015 Jun 5;6:290. doi: 10.3389/fimmu.2015.00290. eCollection 2015.
Immunostimulatory agents provide a new category of anti-microbial agents that activate the host's innate immune system allowing control of viral and/or bacterial infections. The TLR-2 agonist PEG-Pam2Cys has been shown to mediate potent anti-viral activity against influenza viruses when administered prophylactically (1). Here, we demonstrate that the treatment of mice with PEG-Pam2Cys does not compromise their ability to generate adaptive immune responses following subsequent challenge with influenza virus. The antibody induced in mice pre-treated with Pam2Cys possessed hemagglutination-inhibiting activities and the CD8(+) T-cell responses that were elicited provided protection against heterologous viral challenge. In the absence of an effective influenza vaccine, an agent that provides immediate protection against the virus and does not compromise the induction of influenza-specific immunity on exposure to infectious virus provides an opportunity for population immunity to be achieved through natural exposure to virus.
免疫刺激剂提供了一类新型抗菌剂，可激活宿主的先天免疫系统，从而控制病毒和/或细菌感染。TLR-2激动剂聚乙二醇化Pam2Cys（PEG-Pam2Cys）已被证明在预防性给药时可介导针对流感病毒的强效抗病毒活性（1）。在此，我们证明用PEG-Pam2Cys治疗小鼠不会损害它们在随后受到流感病毒攻击后产生适应性免疫反应的能力。用Pam2Cys预处理的小鼠诱导产生的抗体具有血凝抑制活性，引发的CD8(+) T细胞反应可提供针对异源病毒攻击的保护。在缺乏有效流感疫苗的情况下，一种能立即提供针对病毒的保护且在接触感染性病毒时不损害流感特异性免疫诱导的药物，为通过自然接触病毒实现群体免疫提供了机会。
