Jin Zhong, Xu Naijin, Guo Kai, Xu Peng, Li Pengju, Zhang Yiming, Li Xiezhao, Zheng Shaobo, Liu Chunxiao, Xu Abai, Huang Peng
Department of Urology, Zhujiang Hospital, Southern Medical University Guangzhou, People's Republic of China.
Department of The 1st Urology, The 2nd Hospital of Dalian Medical University Dalian, People's Republic of China.
Int J Clin Exp Pathol. 2015 Apr 1;8(4):3857-63. eCollection 2015.
Metastasis-associated in colon cancer-1 (MACC1) expression in tumor specimens is an independent prognostic indicator of metastasis, which has recently gained considerable attention in cancer research, due to its overexpression in several types of carcinoma. However, MACC1 expression patterns and its possible role in renal cell carcinoma remain unknown. This study aimed to investigate MACC1 expression in renal cell carcinoma via immunohistochemical analysis and determine the relationship between MACC1 expression and cancer prognosis. Positive MACC1 expression was found to significantly correlate with distant metastasis and TNM stage (P < 0.05). A Kaplan-Meier survival analysis revealed that patients with higher MACC1 expression had a significantly lower disease-free rate (P < 0.05). These results indicate that MACC1 expression is significantly associated with prognosis in patients with renal cell carcinoma. To the best of our knowledge, this is the first study on the significance of MACC1 as a prognostic marker in renal cell carcinoma. MACC1 expression may be a useful target for the development of new therapeutic approaches, including molecular targeted therapeutic agents, for renal cell carcinoma.
结肠癌转移相关蛋白1（MACC1）在肿瘤标本中的表达是转移的独立预后指标，由于其在多种类型的癌中过表达，最近在癌症研究中受到了相当大的关注。然而，MACC1在肾细胞癌中的表达模式及其可能的作用仍不清楚。本研究旨在通过免疫组化分析研究MACC1在肾细胞癌中的表达，并确定MACC1表达与癌症预后之间的关系。发现MACC1阳性表达与远处转移和TNM分期显著相关（P < 0.05）。Kaplan-Meier生存分析显示，MACC1表达较高的患者无病生存率显著较低（P < 0.05）。这些结果表明，MACC1表达与肾细胞癌患者的预后显著相关。据我们所知，这是第一项关于MACC1作为肾细胞癌预后标志物意义的研究。MACC1表达可能是开发包括分子靶向治疗药物在内的肾细胞癌新治疗方法的有用靶点。
