Karp Peter D, Berger Bonnie, Kovats Diane, Lengauer Thomas, Linial Michal, Sabeti Pardis, Hide Winston, Rost Burkhard
International Society for Computational Biology, La Jolla, CA, USA ; SRI International, Menlo Park, CA, USA.
International Society for Computational Biology, La Jolla, CA, USA ; Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA, USA.
F1000Res. 2015 Jan 15;4:12. doi: 10.12688/f1000research.6038.1. eCollection 2015.
Speed is of the essence in combating Ebola; thus, computational approaches should form a significant component of Ebola research. As for the development of any modern drug, computational biology is uniquely positioned to contribute through comparative analysis of the genome sequences of Ebola strains as well as 3-D protein modeling. Other computational approaches to Ebola may include large-scale docking studies of Ebola proteins with human proteins and with small-molecule libraries, computational modeling of the spread of the virus, computational mining of the Ebola literature, and creation of a curated Ebola database. Taken together, such computational efforts could significantly accelerate traditional scientific approaches. In recognition of the need for important and immediate solutions from the field of computational biology against Ebola, the International Society for Computational Biology (ISCB) announces a prize for an important computational advance in fighting the Ebola virus. ISCB will confer the ISCB Fight against Ebola Award, along with a prize of US$2,000, at its July 2016 annual meeting (ISCB Intelligent Systems for Molecular Biology (ISMB) 2016, Orlando, Florida).
速度是对抗埃博拉病毒的关键所在；因此，计算方法应成为埃博拉研究的重要组成部分。就任何现代药物的研发而言，计算生物学凭借对埃博拉病毒株基因组序列的比较分析以及三维蛋白质建模，具有独特的贡献能力。针对埃博拉病毒的其他计算方法可能包括对埃博拉病毒蛋白与人蛋白以及小分子文库进行大规模对接研究、病毒传播的计算建模、埃博拉文献的计算挖掘，以及创建一个经过整理的埃博拉数据库。综合来看，这些计算方面的努力能够显著加速传统科学方法。认识到计算生物学领域需要针对埃博拉病毒提供重要且即时的解决方案，国际计算生物学学会（ISCB）宣布设立一项奖项，用于奖励在对抗埃博拉病毒方面取得的重要计算进展。ISCB 将在其 2016 年 7 月的年会（ISCB 分子生物学智能系统大会（ISMB）2016，佛罗里达州奥兰多）上颁发 ISCB 抗击埃博拉奖以及 2000 美元奖金。
