Bertoglio S, Melioli G, Baldini E, Catturich A, Sertoli M R, Civalleri D, Percivale P, Meier W, Galazka A, Badellino F
Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.
Acta Med Austriaca. 1989;16(3-4):81-3.
In a phase-I-study recombinant interleukin-2 (rIL-2) in a dose from 0.01 to 0.3 mg/m2/day for 7 to 14 days was infused intraperitoneally. Side effects were fever and fluid retention. 2 patients showed a bacterial peritonitis after paracentesis. The investigations showed that the intraperitoneal (i.p.) administration of interleukin-2 activates the whole lymphokine cascade.
在一项I期研究中，以0.01至0.3毫克/平方米/天的剂量腹腔内输注重组白细胞介素-2（rIL-2），持续7至14天。副作用为发热和液体潴留。2例患者在腹腔穿刺术后发生细菌性腹膜炎。研究表明，腹腔内给予白细胞介素-2可激活整个淋巴因子级联反应。
