[2-对（二甲氨基）苯乙烯基]吡啶甲基碘化物对小鼠和兔子的作用
[Effects of 2[p-(dimethylamino)styryl] pyridine methiodide on mouse and rabbit].
作者信息
Zhou C M, Zhang K J, Wang X W, Bai L, Mao X M
出版信息
Zhongguo Yao Li Xue Bao. 1989 May;10(3):239-41.
The effects of 2[p-(dimethylamino)styryl] pyridine methiodide on mouse and rabbit ECG and on the contraction of isolated rabbit atrial muscles were studied. DSPM produced long-lasting bradycardia and A-V block in a dose-dependent manner, but did not effect intraventricular conduction. DSPM antagonized the positive chronotropic and dromotropic effects of isoprenaline (Iso) in vivo, and antagonized the inotropic effects of Iso and CaCl2 non-competitively in vitro. The pD'2 were 4.49 and 4.52, respectively. It is suggested that DSPM may be a Ca2+ antagonist.
研究了2-对（二甲氨基）苯乙烯基吡啶甲碘化物对小鼠和家兔心电图以及对家兔离体心房肌收缩的影响。2-对（二甲氨基）苯乙烯基吡啶甲碘化物以剂量依赖的方式产生持久的心动过缓和房室传导阻滞，但不影响室内传导。2-对（二甲氨基）苯乙烯基吡啶甲碘化物在体内拮抗异丙肾上腺素（Iso）的正性变时和变传导作用，在体外非竞争性拮抗Iso和氯化钙的变力作用。pD’2分别为4.49和4.52。提示2-对（二甲氨基）苯乙烯基吡啶甲碘化物可能是一种钙拮抗剂。
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