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替加环素治疗期间获得假单胞菌属和变形杆菌属的危险因素的病例对照研究。

Case-control study of the risk factors for acquisition of Pseudomonas and Proteus species during tigecycline therapy.

作者信息

Park Ga Eun, Kang Cheol-In, Wi Yu Mi, Ko Jae-Hoon, Lee Woo Joo, Lee Ji Yong, Cho Sun Young, Ha Young Eun, Chung Doo Ryeon, Peck Kyong Ran, Song Jae-Hoon

机构信息

Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

出版信息

Antimicrob Agents Chemother. 2015 Sep;59(9):5830-3. doi: 10.1128/AAC.04865-14. Epub 2015 Jun 22.

Abstract

Tigecycline is an important agent in clinical practice because of its broad-spectrum activity. However, it has no activity against Pseudomonas or Proteus species. We conducted a case-control study to analyze risk factors for the acquisition of Pseudomonas or Proteus spp. during tigecycline therapy. Placement of suction drainage at infected wound sites, ICU stay, and neurologic disease were identified as independent risk factors for the acquisition of Pseudomonas and Proteus spp.

摘要

替加环素因其广谱活性而成为临床实践中的一种重要药物。然而,它对假单胞菌属或变形杆菌属无活性。我们进行了一项病例对照研究,以分析替加环素治疗期间获得假单胞菌属或变形杆菌属的危险因素。在感染伤口部位放置吸引引流、入住重症监护病房(ICU)和神经系统疾病被确定为获得假单胞菌属和变形杆菌属的独立危险因素。

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