沙特阿拉伯高海拔地区学童的环境、尿碘状况与甲状腺肿患病率

Environmental, urinary iodine status and prevalence of goitre among schoolchildren in a high altitude area of Saudi Arabia.

作者信息

Omar Mohamed Salah, El-Sayed Desouky Dalia

机构信息

Mohamed Salah Omar, Chemistry Department, Faculty of Science, Benha University, Benha, Qalyubia, Egypt. Division of Biochemistry, Department of Pharmacology, College of Clinical Pharmacy, Taif University, Al-Haweiah, Taif 21974, Saudi Arabia.

Dalia El-Sayed Desouky, Department of Public Health and Community Medicine, Faculty of Medicine, Menoufyia University, Shebin El-Kom, Egypt. Department of Public Health and Community Medicine, Faculty of Medicine, Taif University, Al-Haweiah, Taif 21974, Saudi Arabia.

出版信息

Pak J Med Sci. 2015 Mar-Apr;31(2):414-9. doi: 10.12669/pjms.312.6637.

DOI:10.12669/pjms.312.6637

PMID:26101502

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4476353/

Abstract

OBJECTIVE

This study aimed to assess the iodine deficiency, prevalence of goitre among schoolchildren and measuring environmental iodine in Taif city, Saudi Arabia.

METHODS

A cross-sectional multistage cluster-sampling methodology was done on 1887 schoolchildren. Their urinary iodine concentration (UIC) and goitre prevalence was assessed. Blood level of triiodothyronin, thyroxine and thyroid-stimulating-hormone was carried out for students with normal, mild; moderate and sever iodine deficiency. The iodine content of salt, water and soil was also assessed.

RESULTS

Goitre prevalence was 7.4% and about 71% of the participants had UIC less than 100μg/L. An inverse relationship between median UIC and the percent prevalence of goitre was found. The mean serum T3, T4 and TSH were 1.05ng/dL, 6.81µg/dL, and 5.69mIU/L, respectively. A significant positive correlation was found between the mean value of urinary iodine and the mean value of both T3 and T4. While a significant negative correlation between the mean value of urinary iodine and the mean value of TSH was also noted.

CONCLUSIONS

The results revealed the presence of a potential public health problem of iodine deficiency among school going children in high altitude areas of Saudi Arabia. There is a need to monitor and evaluate the salt iodization process, and distribute adequately iodized salt in the affected areas.

摘要

目的

本研究旨在评估沙特阿拉伯塔伊夫市学童的碘缺乏情况、甲状腺肿患病率以及测量环境碘含量。

方法

对1887名学童采用横断面多阶段整群抽样方法。评估他们的尿碘浓度（UIC）和甲状腺肿患病率。对碘缺乏正常、轻度、中度和重度的学生进行血清三碘甲状腺原氨酸、甲状腺素和促甲状腺激素水平检测。还评估了盐、水和土壤中的碘含量。

结果

甲状腺肿患病率为7.4%，约71%的参与者尿碘浓度低于100μg/L。发现尿碘中位数与甲状腺肿患病率百分比之间呈负相关。血清T3、T4和TSH的平均值分别为1.05ng/dL、6.81μg/dL和5.69mIU/L。尿碘平均值与T3和T4平均值之间存在显著正相关。同时，尿碘平均值与TSH平均值之间也存在显著负相关。