Martínez R D, Eisenbach L, Feldman M
Subdivisión de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, México City.
Allergol Immunopathol (Madr). 1989 Sep-Oct;17(5):257-61.
The effect of tobacco products (TP) on the proliferation of lung adenocarcinoma cells (3LL) and mice spleen lymphocytes as well as on tumor growth and metastasis was analyzed. High concentrations of cigarette smoke condensate (CSC) or tobacco extract (TE) were cytotoxic for tumoral and lymphoid cells; in contrast smaller amounts of TP increased thymidine incorporation in both cell types. Lymphocytes were more susceptible to the toxic effect of TP than 3LL cells. When CSC or TE were mixed with 3LL cells and then inoculated into mice, they did not modify either the size of the local tumor induced by 3LL cells, or the number or appearance time of lung metastasis, although there was an increase in spleen weight.
分析了烟草制品（TP）对肺腺癌细胞（3LL）和小鼠脾脏淋巴细胞增殖以及肿瘤生长和转移的影响。高浓度的香烟烟雾冷凝物（CSC）或烟草提取物（TE）对肿瘤细胞和淋巴细胞具有细胞毒性；相比之下，少量的TP可增加两种细胞类型中胸苷的掺入。淋巴细胞比3LL细胞对TP的毒性作用更敏感。当将CSC或TE与3LL细胞混合然后接种到小鼠体内时，尽管脾脏重量增加，但它们既没有改变3LL细胞诱导的局部肿瘤大小，也没有改变肺转移的数量或出现时间。
