患有妊娠期糖尿病的欧洲裔巴西女性中FTO和TCF7L2基因的多态性。
Polymorphisms in FTO and TCF7L2 genes of Euro-Brazilian women with gestational diabetes.
作者信息
de Melo Sandra Fabrico, Frigeri Henrique Ravanhol, dos Santos-Weiss Izabella Castilhos Ribeiro, Réa Rosângela Roginski, de Souza Emanuel Maltempi, Alberton Dayane, Gomes de Moraes Rego Fabiane, Picheth Geraldo
机构信息
Post-Graduate Program in Pharmaceutical Science, Federal University of Parana, Brazil.
Post-Graduate Program in Pharmaceutical Science, Federal University of Parana, Brazil; Health and Biosciences School, Pontifical Catholic University of Parana, Curitiba, Parana, Brazil.
出版信息
Clin Biochem. 2015 Nov;48(16-17):1064-7. doi: 10.1016/j.clinbiochem.2015.06.013. Epub 2015 Jun 21.
OBJECTIVE
To investigate the association between fat mass and obesity-associated (FTO) gene polymorphisms rs8050136C>A and rs9939609T>A, and transcription factor 7-like 2 (TCF7L2) gene polymorphisms rs12255372G>T and rs7903146C>T, in a sample group of pregnant Euro-Brazilian women with or without gestational diabetes mellitus (GDM).
METHODS
Subjects were classified as either healthy pregnant control (n=200) or GDM (n=200) according to the 2010 criteria of the American Diabetes Association. The polymorphisms were genotyped using fluorescent probes (TaqMan®).
RESULTS
All groups were in the Hardy-Weinberg equilibrium. The genotype and allele frequencies of the examined polymorphisms did not exhibit significant difference (P>0.05) between the groups. In the healthy and GDM pregnant women groups, the A-allele frequencies (95% CI) of FTO polymorphisms rs8050136 and rs9939609 were 39% (34-44%); 38% (33-43%) and 40% (35-45%); 41% (36-46%), respectively; and the T-allele frequencies of TCF7L2 polymorphisms rs12255372 and rs7903146 were 30% (26-35%), 32% (27-37%) and 29% (25-34%), 36% (31-41%), respectively.
CONCLUSION
The examined polymorphisms were not associated with GDM in the Euro-Brazilian population studied.
目的
在患有或未患有妊娠期糖尿病（GDM）的欧洲裔巴西孕妇样本组中，研究脂肪量和肥胖相关（FTO）基因多态性rs8050136C>A和rs9939609T>A，以及转录因子7样2（TCF7L2）基因多态性rs12255372G>T和rs7903146C>T之间的关联。
方法
根据美国糖尿病协会2010年标准，将受试者分为健康妊娠对照组（n = 200）或GDM组（n = 200）。使用荧光探针（TaqMan®）对多态性进行基因分型。
结果
所有组均处于哈迪-温伯格平衡。所检测多态性的基因型和等位基因频率在各组之间未表现出显著差异（P>0.05）。在健康和GDM孕妇组中，FTO多态性rs8050136和rs9939609的A等位基因频率（95%CI）分别为39%（34 - 44%）；38%（33 - 43%）和40%（35 - 45%）；41%（36 - 46%），而TCF7L2多态性rs12255372和rs7903146的T等位基因频率分别为30%（26 - 35%），32%（27 - 37%）和29%（25 - 34%），36%（31 - 41%）。
结论
在所研究的欧洲裔巴西人群中，所检测的多态性与GDM无关。
Zotero 插件