TGIF1促进非小细胞肺癌中癌细胞的生长和迁移。
TGIF1 promoted the growth and migration of cancer cells in nonsmall cell lung cancer.
作者信息
Xiang Guo, Yi Yang, Weiwei He, Weiming Wu
机构信息
Department of Thoracic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
出版信息
Tumour Biol. 2015 Dec;36(12):9303-10. doi: 10.1007/s13277-015-3676-8. Epub 2015 Jun 24.
Transforming growth factor beta-inducing factor 1 (TGIF1) was reported to be dysregulated in several types of cancer. However, its expression pattern and functions in nonsmall cell lung cancer (NSCLC) remained unknown. In the present study, the expression of TGIF1 was found to be elevated in the clinical NSCLC tissues. TGIF1 promoted the growth and migration of NSCLC cells, while knocking down the expression of TGIF1 inhibited the growth and migration of NSCLC cells. Moreover, downregulation of TGIF1 impaired the metastasis of NSCLC cells. In the study for the molecular mechanisms, it was found that TGIF1 positively regulated beta-catenin/TCF signaling. In summary, our study demonstrated the oncogenic role of TGIF1 in NSCLC, and TGIF1 might be a therapeutic target for NSCLC.
据报道，转化生长因子β诱导因子1（TGIF1）在多种癌症中表达失调。然而，其在非小细胞肺癌（NSCLC）中的表达模式和功能仍不清楚。在本研究中，发现TGIF1在临床NSCLC组织中表达升高。TGIF1促进NSCLC细胞的生长和迁移，而敲低TGIF1的表达则抑制NSCLC细胞的生长和迁移。此外，TGIF1的下调会损害NSCLC细胞的转移。在分子机制研究中，发现TGIF1正向调节β-连环蛋白/TCF信号通路。总之，我们的研究证明了TGIF1在NSCLC中的致癌作用，TGIF1可能是NSCLC的一个治疗靶点。
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