Postel-Vinay M C
INSERM U.30 Unité de Recherches en Biologie et Pathologie de la Croissance et du Développement, Hôpital des Enfants-Malades, Paris.
Ann Endocrinol (Paris). 1989;50(5):404-8.
Specific binding sites for growth hormone (GH) have been found in a variety of tissues. The rabbit liver GH receptor has recently been purified, sequenced and cloned. It is a polypeptide chain of 620 aminoacids with a single transmembrane domain. The sequence of the extracellular hormone binding domain of the receptor is identical to the sequence of the serum binding protein. The intra-cellular signalling mechanism is not known. The GH receptor gene(s) has to be studied. Rapid and great changes in the number of GH receptors have been demonstrated in situations of growth defect in rats. GH and insulin both play an important role in the regulation of GH sites, but the mechanisms of regulation remain to be clarified. Studies with monoclonal antibodies against the GH receptor and also sequence analysis and cloning of cDNA from different tissues should help to answer the question of the multiplicity of the GH receptors.
生长激素（GH）的特异性结合位点已在多种组织中被发现。兔肝脏生长激素受体最近已被纯化、测序和克隆。它是一条由620个氨基酸组成的多肽链，具有一个单一的跨膜结构域。受体细胞外激素结合域的序列与血清结合蛋白的序列相同。细胞内信号传导机制尚不清楚。必须对生长激素受体基因进行研究。在大鼠生长缺陷的情况下，已证明生长激素受体数量会迅速且大幅变化。生长激素和胰岛素在生长激素位点的调节中都起着重要作用，但调节机制仍有待阐明。使用针对生长激素受体的单克隆抗体进行的研究以及对来自不同组织的cDNA进行序列分析和克隆，应该有助于回答生长激素受体多样性的问题。
