昼夜节律中的代谢与神经发育的表观遗传机制。
Epigenetic mechanisms in diurnal cycles of metabolism and neurodevelopment.
作者信息
Powell Weston T, LaSalle Janine M
机构信息
Medical Microbiology and Immunology, Genome Center, MIND Institute, University of California, Davis, CA 95616, USA.
Medical Microbiology and Immunology, Genome Center, MIND Institute, University of California, Davis, CA 95616, USA
出版信息
Hum Mol Genet. 2015 Oct 15;24(R1):R1-9. doi: 10.1093/hmg/ddv234. Epub 2015 Jun 23.
The circadian cycle is a genetically encoded clock that drives cellular rhythms of transcription, translation and metabolism. The circadian clock interacts with the diurnal environment that also drives transcription and metabolism during light/dark, sleep/wake, hot/cold and feast/fast daily and seasonal cycles. Epigenetic regulation provides a mechanism for cells to integrate genetic programs with environmental signals in order produce an adaptive and consistent output. Recent studies have revealed that DNA methylation is one epigenetic mechanism that entrains the circadian clock to a diurnal environment. We also review recent circadian findings in the epigenetic neurodevelopmental disorders Prader-Willi, Angelman and Rett syndromes and hypothesize a link between optimal brain development and intact synchrony between circadian and diurnal rhythms.
昼夜节律循环是一种由基因编码的时钟，它驱动细胞的转录、翻译和代谢节律。昼夜节律时钟与昼夜环境相互作用，在光/暗、睡眠/清醒、热/冷以及日常和季节性的进食/禁食循环中，昼夜环境也驱动转录和代谢。表观遗传调控为细胞提供了一种机制，使其能够将遗传程序与环境信号整合起来，从而产生适应性和一致性的输出。最近的研究表明，DNA甲基化是一种表观遗传机制，它使昼夜节律时钟与昼夜环境同步。我们还回顾了最近在表观遗传神经发育障碍普拉德-威利综合征、天使综合征和雷特综合征中的昼夜节律研究结果，并推测最佳大脑发育与昼夜节律和昼夜节奏之间完整的同步性之间存在联系。
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