Smolianskaia A Z
Antibiot Khimioter. 1989 Sep;34(9):696-9.
Rational antibacterial therapy of infections in oncological patients in relation to the polyetiological nature of the infections and polyresistance of their causative agents contemplates the use of drug combinations. The necessity of long-term antibacterial therapy in many oncological patients also predisposes to it. The choice of drugs for every patient should stem from bacteriological findings: isolation of the pathogen, its identification and assay of its antibiotic sensitivity. When isolation of the causative agent is not possible or could not be done immediately the drug should be chosen according to the general data on the etiological structure of infectious complications in the particular department and particular pathological process as well as antibiotic sensitivity of the bacteria isolated under such conditions.
鉴于肿瘤患者感染的多病因性质及其病原体的多重耐药性,合理的抗菌治疗需要使用联合药物。许多肿瘤患者需要长期抗菌治疗,这也促使了联合用药的必要性。每位患者的用药选择应基于细菌学检查结果:病原体的分离、鉴定及其抗生素敏感性测定。当无法立即分离出病原体时,应根据特定科室和特定病理过程中感染并发症的病因结构的一般数据以及在此类情况下分离出的细菌的抗生素敏感性来选择药物。