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[丁型病毒性肝炎的肝脏形态学]

[Liver morphology in delta virus hepatitis].

作者信息

Loginov A S, Aruin L I, Shatalova O L, Krenchyk D, Ponomarenko A M

出版信息

Arkh Patol. 1989;51(10):18-25.

PMID:2610600
Abstract

Biopsy material from two groups of patients with liver diseases is studied. 12 patients with a high titer of total anti-delta (D)-antibodies are included into the 1st group. In this group, among patients with total antibodies to D-infection D-antigen in the liver tissue is found in 6 cases with a pronounced chronic aggressive hepatitis (CAH) and active liver cirrhosis (ALC). The 2nd group consisted of 30 patients with CAH and ALC and D-antigen was observed in 10 cases. Hepatocyte degeneration and pronounced lobular infiltration were the only distinctive feature of liver morphology in D-positive cases as compared to the D-negative ones. The presence of D-antigen always correlated with an active inflammatory process.

摘要

对两组肝病患者的活检材料进行了研究。第一组纳入了12例总抗δ(D)抗体滴度高的患者。在该组中,在6例患有明显慢性侵袭性肝炎(CAH)和活动性肝硬化(ALC)的肝脏组织中发现了D感染D抗原的总抗体患者。第二组由30例CAH和ALC患者组成,其中10例观察到D抗原。与D阴性病例相比,D阳性病例肝脏形态的唯一显著特征是肝细胞变性和明显的小叶浸润。D抗原的存在始终与活跃的炎症过程相关。

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