一名16岁男性肺部起源的组织细胞肉瘤

Histiocytic Sarcoma Originating in the Lung in a 16-Year-Old Male.

作者信息

Tomita Sakura, Ogura Go, Inomoto Chie, Kajiwara Hiroshi, Masuda Ryota, Iwazaki Masayuki, Kojima Masaru, Nakamura Naoya

机构信息

Department of Pathology Department of Surgery, Tokai University School of Medicine.

出版信息

J Clin Exp Hematop. 2015;55(1):45-9. doi: 10.3960/jslrt.55.45.

DOI:10.3960/jslrt.55.45

PMID:26106007

Abstract

We report a 16-year-old male with histiocytic sarcoma (HS) originating in the lung. Partial resection of the lung was performed for a 3-cm mass with a clear boundary detected in the right inferior pulmonary lobe on a health checkup. Histologically, the tumor infiltrated into the surrounding tissue, and was comprised of spindle cells, mainly, and foam cells accompanied by mild nuclear atypia. The tumor cells were immunohistochemically positive for CD68 and CD163, indicating histiocytic lineage and the MIB-1-positive rate was low. Spindle cell morphology of HS is quite rare and only 3 cases of pulmonary HS have previously been reported.

摘要

我们报告一例起源于肺的组织细胞肉瘤（HS）的16岁男性患者。在健康检查中，对右下肺叶发现的一个边界清晰的3厘米肿块进行了肺部分切除术。组织学上，肿瘤浸润至周围组织，主要由梭形细胞和伴有轻度核异型性的泡沫细胞组成。肿瘤细胞免疫组化CD68和CD163呈阳性，表明为组织细胞谱系，且MIB-1阳性率较低。HS的梭形细胞形态非常罕见，此前仅报道过3例肺HS病例。