具有破坏作用的环境化学物质以及赋予细胞对死亡抗性的细胞机制。
Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death.
作者信息
Narayanan Kannan Badri, Ali Manaf, Barclay Barry J, Cheng Qiang Shawn, D'Abronzo Leandro, Dornetshuber-Fleiss Rita, Ghosh Paramita M, Gonzalez Guzman Michael J, Lee Tae-Jin, Leung Po Sing, Li Lin, Luanpitpong Suidjit, Ratovitski Edward, Rojanasakul Yon, Romano Maria Fiammetta, Romano Simona, Sinha Ranjeet K, Yedjou Clement, Al-Mulla Fahd, Al-Temaimi Rabeah, Amedei Amedeo, Brown Dustin G, Ryan Elizabeth P, Colacci Annamaria, Hamid Roslida A, Mondello Chiara, Raju Jayadev, Salem Hosni K, Woodrick Jordan, Scovassi A Ivana, Singh Neetu, Vaccari Monica, Roy Rabindra, Forte Stefano, Memeo Lorenzo, Kim Seo Yun, Bisson William H, Lowe Leroy, Park Hyun Ho
机构信息
Department of Chemistry and Biochemistry, Yeungnam University, Gyeongsan 712-749, South Korea, Sultan Zainal Abidin University, Malaysia, Plant Biotechnologies Inc, St. Albert AB, Canada, Computer Science Department, Southern Illinois University, Carbondale, IL 62901, USA, Department of Urology, University of California Davis, Sacramento, CA 95817, USA, Department of Pharmacology and Toxicology, University of Vienna, Austria, University of Puerto Rico, Medical Sciences Campus, School of Public Health, Nutrition Program, San Juan Puerto Rico 00936-5067, USA, Department of Anatomy, College of Medicine, Yeungnam University, Daegu, 705-717, South Korea, School of Biomedical Science, The Chinese University Of Hong Kong, Hong Kong, China, Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand, Department of Otolaryngology/Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA, Department of Pharmaceutical Sciences, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA, Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, 80131 Naples, Italy, Department of Molecular and Experimental Medicine, MEM 180, The Scripps Research Institute, La Jolla, CA 92037, USA, Department of Biology, Jackson State University, Jackson, MS 39217, USA, Department of Pathology, Kuwait University, Safat 13110, Kuwait, Department of Experimental and Clinical Medicine, University of Firenze, Firenze, 50134, Italy, Department of Environmental and Radiological Health Sciences, Colorado state University/ Colorado School of Public Health, Fort Collins, CO 80523-1680, USA, Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna, 40126, Italy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Se
Sultan Zainal Abidin University, Malaysia.
出版信息
Carcinogenesis. 2015 Jun;36 Suppl 1(Suppl 1):S89-110. doi: 10.1093/carcin/bgv032.
Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically, the up-regulation of pro-survival factors, including oncogenic factors and antiapoptotic signaling pathways, and the down-regulation of pro-apoptotic factors, including tumor suppressive factors, confers resistance to cell death in tumor cells, which supports the emergence of a fully immortalized cellular phenotype. This review considers the potential relevance of ubiquitous environmental chemical exposures that have been shown to disrupt key pathways and mechanisms associated with this sort of dysfunction. Specifically, bisphenol A, chlorothalonil, dibutyl phthalate, dichlorvos, lindane, linuron, methoxychlor and oxyfluorfen are discussed as prototypical chemical disruptors; as their effects relate to resistance to cell death, as constituents within environmental mixtures and as potential contributors to environmental carcinogenesis.
细胞死亡是生物细胞内停止发挥功能的死亡过程。这一过程对于调节生物体发育、组织稳态以及清除体内遭受不可修复损伤的细胞至关重要。一般而言，正常细胞死亡功能障碍与癌症进展密切相关。具体来说，包括致癌因子和抗凋亡信号通路在内的促生存因子上调，以及包括肿瘤抑制因子在内的促凋亡因子下调，赋予肿瘤细胞对细胞死亡的抗性，从而支持完全永生化细胞表型的出现。本综述探讨了普遍存在的环境化学暴露的潜在相关性，这些暴露已被证明会破坏与这种功能障碍相关的关键途径和机制。具体而言，双酚A、百菌清、邻苯二甲酸二丁酯、敌敌畏、林丹、利谷隆、甲氧滴滴涕和乙氧氟草醚作为典型的化学干扰物进行了讨论；讨论内容涉及其与细胞死亡抗性的关系、作为环境混合物中的成分以及作为环境致癌作用的潜在促成因素。
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