Yao Qinfan, Zhang Xiuyuan, Chen Dajin
Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, China.
Front Oncol. 2022 Feb 25;12:848296. doi: 10.3389/fonc.2022.848296. eCollection 2022.
Numerous long noncoding RNAs (lncRNAs) have been identified as powerful regulators of human diseases. The lncRNA FOXD3-AS1 is a novel lncRNA that was recently shown to exert imperative roles in the initialization and progression of several diseases. Emerging studies have shown aberrant expression of FOXD3-AS1 and close correlation with pathophysiological traits of numerous diseases, particularly cancers. More importantly, FOXD3-AS1 was also found to ubiquitously impact a range of biological functions. This study aims to summarize the expression, associated clinicopathological features, major functions and molecular mechanisms of FOXD3-AS1 in human diseases and to explore its possible clinical applications.
众多长链非编码RNA（lncRNAs）已被确定为人类疾病的强大调节因子。长链非编码RNA FOXD3-AS1是一种新型lncRNA，最近研究表明它在多种疾病的发生和发展过程中发挥着重要作用。新兴研究显示FOXD3-AS1表达异常，且与多种疾病，尤其是癌症的病理生理特征密切相关。更重要的是，还发现FOXD3-AS1普遍影响一系列生物学功能。本研究旨在总结FOXD3-AS1在人类疾病中的表达、相关临床病理特征、主要功能和分子机制，并探索其可能的临床应用。
