Koniarek J P
Department of Ophthalmology, Columbia University College of Physicians and Surgeons, New York NY.
Bioelectromagnetics. 1989;10(4):335-45. doi: 10.1002/bem.2250100402.
A unique tension response can be obtained by stimulating an isometrically held skeletal muscle or a single muscle fiber by a train of high-frequency pulses (2,000 pps) at higher-than-normal intensity, or by a long DC pulse. It is called the tetanoid response, and it is composed of three well-defined stages. Initially, tension develops rapidly, and mechanical output (Po) reaches about 0.35. Subsequently, this tension is maintained at a nearly steady level for the remainder of stimulation. After stimulation, a final increase of tension takes place. Intracellular electrical recordings show that the initial development of tension is elicited by two or three action potentials generated at the beginning of the stimulation, and that no additional action potentials are generated for the remainder of stimulation. During stimulation, part of the fiber membrane (regarded in cross-section) is depolarized, which generates tension, and part of the membrane is hyperpolarized. With termination of stimulation, a single action potential is elicited via anode-break excitation (ABE) on the hyperpolarized portion of the membrane, which gives rise to the final increase of tension.
通过以高于正常强度的一系列高频脉冲（2000次/秒）或长直流脉冲刺激等长收缩的骨骼肌或单个肌纤维，可获得一种独特的张力反应。它被称为强直样反应，由三个明确的阶段组成。最初，张力迅速发展，机械输出（Po）达到约0.35。随后，在刺激的剩余时间内，这种张力保持在几乎稳定的水平。刺激后，张力会出现最终增加。细胞内电记录表明，张力的最初发展是由刺激开始时产生的两三个动作电位引发的，并且在刺激的剩余时间内不会产生额外的动作电位。在刺激期间，纤维膜的一部分（在横截面上观察）去极化，产生张力，而膜的一部分则超极化。随着刺激的终止，通过膜超极化部分上的阳极断电激发（ABE）引发单个动作电位，这导致张力的最终增加。
