接受化疗的犬类血液涂片中有核红细胞。
Nucleated erythrocytes in blood smears of dogs undergoing chemotherapy.
作者信息
Moretti P, Giordano A, Stefanello D, Ferrari R, Castellano S, Paltrinieri S
机构信息
Department of Veterinary Sciences and Public Health, University of Milan, Milan, Italy.
Central Laboratory, University Teaching Hospital, University of Milan, Lodi, Italy.
出版信息
Vet Comp Oncol. 2017 Mar;15(1):215-225. doi: 10.1111/vco.12156. Epub 2015 Jun 25.
The frequency of normoblastemia in dogs receiving chemotherapy is unknown. To provide this information, we calculated the percentage and number of nucleated erythrocytes (nRBCs) in blood of dogs treated for lymphoma (n = 284), mast cell tumour (n = 40) or carcinoma (n = 46). Relative normoblastemia (>1 or >5%) and absolute normoblastemia (>0.1 or >0.4 × 10 µL ) were found after administration of vincristine (49.3, 20.5, 42.5, 19.2%, respectively), carboplatin (37.0, 2.2, 34.8, 13.0%), cyclophosphamide (30.8, 7.7, 23.1, 7.7%), doxorubicin (25.0, 8.3, 21.7, 6.7%), vinblastine and prednisone (25.0; 5.0; 22.5; 7.5%). Absolute normoblastemia was very severe (>1.0 × 10 nRBC µL ) after administration of vincristine (9.6%), doxorubicin (3.3%), vinblastine and prednisone (2.5%). Absolute normoblastemia negatively correlated with RBC counts (P < 0.001) and positively (P < 0.001) with reticulocyte and WBC counts, but correlation coefficients were low (-0.19, 0.37, 0.15). Vincristine, doxorubicin or vinblastine and prednisone may induce severe normoblastemia. This may increase WBC counts and mask neutropenia associated with chemotherapy.
接受化疗的犬类中出现幼红细胞血症的频率尚不清楚。为了获取这一信息，我们计算了接受淋巴瘤治疗（n = 284）、肥大细胞瘤治疗（n = 40）或癌治疗（n = 46）的犬类血液中有核红细胞（nRBCs）的百分比和数量。在给予长春新碱后发现相对幼红细胞血症（>1或>5%）和绝对幼红细胞血症（>0.1或>0.4×10⁹/μL），分别为49.3%、20.5%、42.5%、19.2%，卡铂为37.0%、2.2%、34.8%、13.0%，环磷酰胺为30.8%、7.7%、23.1%、7.7%，多柔比星为25.0%、8.3%、21.7%、6.7%，长春碱和泼尼松为25.0%；5.0%；22.5%；7.5%。给予长春新碱（9.6%）、多柔比星（3.3%）、长春碱和泼尼松（2.5%）后绝对幼红细胞血症非常严重（>1.0×10⁹ nRBC/μL）。绝对幼红细胞血症与红细胞计数呈负相关（P < 0.001），与网织红细胞和白细胞计数呈正相关（P < 0.001），但相关系数较低（-0.19、0.37、0.15）。长春新碱、多柔比星或长春碱和泼尼松可能会诱发严重的幼红细胞血症。这可能会增加白细胞计数并掩盖与化疗相关的中性粒细胞减少症。
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